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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Muscle-derived cells for treatment of iatrogenic sphincter damage and urinary incontinence in men
The Scientific World Journal, Volume 2012, Article 898535, Year 2012
Notification
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Description
Introduction. Aim of this study was to assess the safety and efficacy of injection of autologous muscle-derived cells into the urinary sphincter for treatment of postprostatectomy urinary incontinence in men and to characterize the injected cells prior to transplantation. Methods. 222 male patients with stress urinary incontinence and sphincter damage after uroloical procedures were treated with transurethral injection of autologous muscle-derived cells. The transplanted cells were investigated after cultivation and prior to application by immunocytochemistry using different markers of myogenic differentiation. Feasibility and functionality assessment was achieved with a follow-up of at least 12 months. Results. Follow-up was at least 12 months. Of the 222 treated patients, 120 responded to therapy of whom 26 patients (12) were continent, and 94 patients (42) showed improvement. In 102 (46) patients, the therapy was ineffective. Clinical improvement was observed on average 4.7 months after transplantation and continued in all improved patients. The cells injected into the sphincter were at least 50 of myogenic origin and representative for early stages of muscle cell differentiation. Conclusions. Transurethral injection of muscle-derived cells into the damaged urethral sphincter of male patients is a safe procedure. Transplanted cells represent different phases of myogenic differentiation. © Copyright 2012 H. Gerullis et al.
Authors & Co-Authors
Gerullis, Holger
Germany, Essen
Universitätsklinikum Essen
Germany, Neuss
Städt. Kliniken Neuss - Lukaskrankenhaus Gmbh
Germany, Neuss
German Centre for Assessment and Evaluation of Innovative Techniques in Medicine Dzitm
Eimer, Christoph
Germany, Essen
Universitätsklinikum Essen
Germany, Neuss
German Centre for Assessment and Evaluation of Innovative Techniques in Medicine Dzitm
Georgas, Evangelos
Germany, Essen
Universitätsklinikum Essen
Homburger, M.
Germany, Essen
Universitätsklinikum Essen
El-Baz, Ahmed G.
Egypt, Giza
Clinical Surgical Division
Wishahi, Mohamed
Egypt, Giza
Clinical Surgical Division
Borós, M.
Hungary, Szeged
Szegedi Tudományegyetem Szte
Ecke, Thorsten Holger
Germany, Bad Saarow
Helios Klinikum Bad Saarow
Otto, Thomas
Germany, Essen
Universitätsklinikum Essen
Germany, Neuss
Städt. Kliniken Neuss - Lukaskrankenhaus Gmbh
Germany, Neuss
German Centre for Assessment and Evaluation of Innovative Techniques in Medicine Dzitm
Statistics
Citations: 9
Authors: 9
Affiliations: 6
Identifiers
Doi:
10.1100/2012/898535
e-ISSN:
1537744X
Study Design
Cohort Study
Participants Gender
Male