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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Chlorproguanil/dapsone for the treatment of non-severe plasmodium falciparum malaria in Kenya: A pilot study
Transactions of the Royal Society of Tropical Medicine and Hygiene, Volume 82, No. 3, Year 1988
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Description
Chlorocycloguanil, the active metabolite of chlor-proguanil, was synergistic in vitro with dapsone against 2 culture-adapted Plasmodium falciparum isolates from Kenya; maximal synergy occurred at lower concentrations that it did with pyrimethamine and sulfadoxine. 48 children with asymptomatic P. falciparum infections were treated with chlorproguanil (at a target dose of 1*2 mg/kg) and dapsone (target dose of 1-2 or 2-4 mg/kg); all were free of parasitaemia by day 7. The following numbers had recurrences on days 14, 21, and 28, respectively: 1 of 48, 7 of 47, and 7 of 40. All 39 children treated with pyrimethamine (target dose 1'2 mg/kg) and sulfadoxine (target dose 24 mg/kg) were cleared of infection, while the following had recurrences on days 14, 21, and 28:1 of 39, 2 of 38, and 2 of 36. The rate of decrease in parasitaemia was the same in the 2 groups, and there was no change in haematocrit or haemoglobin during the follow-up. The rate of recurrence in the children receiving chlorporguanil/dapsone was higher, probably because these drugs have a much shorter clearance time than pyrimemamine/sulfadoxine. Chlorproguanil/dapsone is an effective combination for treating P. falciparum malaria and deserves further study. © 1988 Oxford University Press.
Authors & Co-Authors
Watkins, Williams M.
Kenya, Nairobi
Kenya Medical Research Institute
Kenya, Nairobi
Wellcome Trust Research Laboratories Nairobi
Brandling-Bennett, A. David
Kenya, Nairobi
Kenya Medical Research Institute
United States, Atlanta
Centers for Disease Control and Prevention
Nevill, Chris G.
Kenya, Nairobi
Amref Health Africa
Carter, Jane Y.
Kenya, Nairobi
Amref Health Africa
Boriga, David A.
Kenya, Nairobi
Kenya Medical Research Institute
Howelis, R. E.
United Kingdom, Liverpool
Liverpool School of Tropical Medicine
Koech, David Kiprotich
Kenya, Nairobi
Kenya Medical Research Institute
Statistics
Citations: 56
Authors: 7
Affiliations: 5
Identifiers
Doi:
10.1016/0035-9203(88)90133-2
ISSN:
00359203
e-ISSN:
18783503
Research Areas
Infectious Diseases
Maternal And Child Health
Study Design
Cohort Study
Study Locations
Kenya