Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Characteristics of multidrug-resistant tuberculosis in Namibia
BMC Infectious Diseases, Volume 12, Article 385, Year 2012
Notification
URL copied to clipboard!
Description
Background: To describe the epidemiology and possible risk factors for the development of multidrug-resistant tuberculosis (MDR-TB) in Namibia.Methods: Using medical records and patient questionnaires, we conducted a case-control study among patients diagnosed with TB between January 2007 and March 2009. Cases were defined as patients with laboratory-confirmed MDR-TB; controls had laboratory-confirmed drug-susceptible TB or were being treated with WHO Category I or Category II treatment regimens.Results: We enrolled 117 MDR-TB cases and 251 TB controls, of which 100% and 2% were laboratory-confirmed, respectively. Among cases, 97% (113/117) had been treated for TB before the current episode compared with 46% (115/251) of controls (odds ratio [OR] 28.7, 95% confidence interval [CI] 10.3-80.5). Cases were significantly more likely to have been previously hospitalized (OR 1.9, 95% CI 1.1-3.5) and to have had a household member with MDR-TB (OR 5.1, 95% CI 2.1-12.5). These associations remained significant when separately controlled for being currently hospitalized or HIV-infection.Conclusions: MDR-TB was associated with previous treatment for TB, previous hospitalization, and having had a household member with MDR-TB, suggesting that TB control practices have been inadequate. Strengthening basic TB control practices, including expanding laboratory confirmation, directly observed therapy, and infection control, are critical to the prevention of MDR-TB. © 2012 Ricks et al.; licensee BioMed Central Ltd.
Authors & Co-Authors
Ricks, Philip M.
United States, Atlanta
Centers for Disease Control and Prevention
Mavhunga, F.
Namibia, Windhoek
Ministry of Health and Social Services
Modi, Surbhi
United States, Atlanta
Centers for Disease Control and Prevention
Indongo, Rosalia
Namibia, Windhoek
Ministry of Health and Social Services
Zezai, A.
Netherlands, The Hague
Kncv Tuberculosis Foundation
Lambert, Lauren A.
United States, Atlanta
Centers for Disease Control and Prevention
DeLuca, Nickolas
United States, Atlanta
Centers for Disease Control and Prevention
Krashin, Jamie W.
United States, Atlanta
Centers for Disease Control and Prevention
Nakashima, Allyn K.
United States, Atlanta
Centers for Disease Control and Prevention
Holtz, Timothy H.
United States, Atlanta
Centers for Disease Control and Prevention
Statistics
Citations: 33
Authors: 10
Affiliations: 3
Identifiers
Doi:
10.1186/1471-2334-12-385
e-ISSN:
14712334
Research Areas
Health System And Policy
Infectious Diseases
Study Design
Case-Control Study
Study Locations
Namibia