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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
general
Widespread seasonal gene expression reveals annual differences in human immunity and physiology
Nature Communications, Volume 6, Article 7000, Year 2015
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Description
Seasonal variations are rarely considered a contributing component to human tissue function or health, although many diseases and physiological process display annual periodicities. Here we find more than 4,000 protein-coding mRNAs in white blood cells and adipose tissue to have seasonal expression profiles, with inverted patterns observed between Europe and Oceania. We also find the cellular composition of blood to vary by season, and these changes, which differ between the United Kingdom and The Gambia, could explain the gene expression periodicity. With regards to tissue function, the immune system has a profound pro-inflammatory transcriptomic profile during European winter, with increased levels of soluble IL-6 receptor and C-reactive protein, risk biomarkers for cardiovascular, psychiatric and autoimmune diseases that have peak incidences in winter. Circannual rhythms thus require further exploration as contributors to various aspects of human physiology and disease. © 2015 Macmillan Publishers Limited. All rights reserved.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC4432600/bin/ncomms8000-s1.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC4432600/bin/ncomms8000-s2.xls
Authors & Co-Authors
Castro-Dopico, Xaquin
United Kingdom, London
Wellcome Trust
Evangelou, Marina
United Kingdom, London
Wellcome Trust
Pekalski, Marcin L.
United Kingdom, London
Wellcome Trust
Fulford, Anthony J.C.
United Kingdom, London
London School of Hygiene & Tropical Medicine
Hennig, Branwen J.W.
United Kingdom, London
London School of Hygiene & Tropical Medicine
Prentice, Andrew M.
United Kingdom, London
London School of Hygiene & Tropical Medicine
Ziegler, Anette Gabriele
Germany, Munich
Technische Universität München
Bonifacio, Ezio E.
Germany, Dresden
Medizinische Fakultät Carl Gustav Carus
Wallace, Chris
United Kingdom, London
Wellcome Trust
United Kingdom, Cambridge
Cambridge Institute of Public Health
Todd, John A.
United Kingdom, London
Wellcome Trust
Statistics
Citations: 322
Authors: 10
Affiliations: 5
Identifiers
Doi:
10.1038/ncomms8000
ISSN:
20411723
Research Areas
Genetics And Genomics
Mental Health
Noncommunicable Diseases
Study Locations
Gambia