Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Immunogenicity of a protective whole cell mycobacterial vaccine in HIV-infected adults: A phase III study in Tanzania
Vaccine, Volume 28, No. 48, Year 2010
Notification
URL copied to clipboard!
Description
Preventive immunization with whole inactivated Mycobacterium vaccae (MV) confers protection against HIV-associated tuberculosis (TB) in BCG-immunized adults with CD4 counts ≥200 cells/μl. We evaluated the immunogenicity of MV in the 2013 subjects of the phase III DarDarTrial using an interferon gamma (IFN-γ) enzyme linked immunosorbent assay (ELISA), tritiated thymidine lymphocyte proliferation assay (LPA) and an ELISA for antibodies to the TB glycolipid lipoarabinomannan (LAM). MV immunization boosts IFN-γ and LPA responses to MV sonicate, and antibody responses to LAM. Post-immunization immune responses to MV correlated with baseline clinical factors, but the responses did not predict protection from HIV-associated TB. © 2010 Elsevier Ltd.
Authors & Co-Authors
Lahey, Timothy P.
United States, Hanover
Geisel School of Medicine at Dartmouth
Arbeit, Robert D.
United States, Boston
Tufts University School of Medicine
Bakari, Muhammad
Tanzania, Dar es Salaam
Muhimbili University of Health and Allied Sciences
Horsburgh, Charles Robert
United States, Boston
School of Public Health
Matee, Mecky Isaac N.
Tanzania, Dar es Salaam
Muhimbili University of Health and Allied Sciences
Waddell, R.
United States, Hanover
Geisel School of Medicine at Dartmouth
Mtei, Lillian N.
Tanzania, Dar es Salaam
Muhimbili University of Health and Allied Sciences
Vuola, Jenni M.
Finland, Helsinki
Terveyden ja Hyvinvoinnin Laitos
Pallangyo, Kisali J.
Tanzania, Dar es Salaam
Muhimbili University of Health and Allied Sciences
von Reyn, Charles Fordham
United States, Hanover
Geisel School of Medicine at Dartmouth
Statistics
Citations: 41
Authors: 10
Affiliations: 5
Identifiers
Doi:
10.1016/j.vaccine.2010.09.041
ISSN:
0264410X
Research Areas
Infectious Diseases
Maternal And Child Health
Study Locations
Tanzania