Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Patterns of nucleotide and haplotype diversity at ICAM-1 across global human populations with varying levels of malaria exposure
Human Genetics, Volume 132, No. 9, Year 2013
Notification
URL copied to clipboard!
Description
Malaria is one of the strongest selective pressures in recent human evolution. African populations have been and continue to be at risk for malarial infections. However, few studies have re-sequenced malaria susceptibility loci across geographically and genetically diverse groups in Africa. We examined nucleotide diversity at Intercellular adhesion molecule-1 (ICAM-1), a malaria susceptibility candidate locus, in a number of human populations with a specific focus on diverse African ethnic groups. We used tests of neutrality to assess whether natural selection has impacted this locus and tested whether SNP variation at ICAM-1 is correlated with malaria endemicity. We observe differing patterns of nucleotide and haplotype variation in global populations and higher levels of diversity in Africa. Although we do not observe a deviation from neutrality based on the allele frequency distribution, we do observe several alleles at ICAM-1, including the ICAM-1 Kilifi allele, that are correlated with malaria endemicity. We show that the ICAM-1 Kilifi allele, which is common in Africa and Asia, exists on distinct haplotype backgrounds and is likely to have arisen more recently in Asia. Our results suggest that correlation analyses of allele frequencies and malaria endemicity may be useful for identifying candidate functional variants that play a role in malaria resistance and susceptibility. © 2013 Springer-Verlag Berlin Heidelberg.
Authors & Co-Authors
Gomez, Felicia
United States, Philadelphia
University of Pennsylvania
United States, Washington, D.c.
The George Washington University
United States, Washington, D.c.
Center for the Advanced Study of Human Paleobiology
United States, St. Louis
Washington University School of Medicine in St. Louis
Tomas, Gil
Portugal, Porto
Universidade do Porto
Ko, Wenya
United States, Philadelphia
University of Pennsylvania
Portugal, Fornelo e Vairao
Cibio - Centro de Investigação em Biodiversidade e Recursos Genéticos
Ranciaro, Alessia
United States, Philadelphia
University of Pennsylvania
Froment, Alain
France, Paris
Umr 208
Ibrahim, Muntaser Eltayeb
Sudan, Khartoum
Institute of Endemic Diseases Sudan
Lema, Godfrey
Tanzania, Dar es Salaam
Muhimbili University of Health and Allied Sciences
Nyambo, Thomas B.
Tanzania, Dar es Salaam
Muhimbili University of Health and Allied Sciences
Omar, Sabah Ahmed
Kenya, Nairobi
Kenya Medical Research Institute
Wambebe, Charles O.
Nigeria, Abuja
International Biomedical Research in Africa
Hirbo, Jibril B.
United States, Philadelphia
University of Pennsylvania
Rocha, J. L.
Portugal, Porto
Universidade do Porto
Portugal, Fornelo e Vairao
Cibio - Centro de Investigação em Biodiversidade e Recursos Genéticos
Tishkoff, Sarah A.
United States, Philadelphia
University of Pennsylvania
Statistics
Citations: 13
Authors: 13
Affiliations: 11
Identifiers
Doi:
10.1007/s00439-013-1284-5
ISSN:
03406717
e-ISSN:
14321203
Research Areas
Genetics And Genomics
Infectious Diseases