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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Oral Squamous Cell Carcinoma: A Clinicopathologic Review of 233 Cases in Lagos, Nigeria
Journal of Oral and Maxillofacial Surgery, Volume 66, No. 8, Year 2008
Notification
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Description
Purpose: The aim of this study is to present the clinicopathologic characteristics of histologically diagnosed squamous cell carcinoma (SCC) of the oral cavity in Lagos, Nigeria, with a view toward analyzing the age, gender, site distribution, and histological differentiation. Patients and Methods: All cases that were histologically diagnosed as SCC of the oral cavity between January 1995 and December 2005 were retrieved from the records of the Department of Oral Pathology and Biology, Lagos University Teaching Hospital and the Oral Pathology Service, Lagos State General Hospitals. All the cases were subjected to analysis of age, gender, site of occurrence, symptoms at presentation, and histological differentiation of tumors. Results: Oral SCC constituted 10.8% (n = 233) of the 5,124 biopsy specimens obtained in all of the centers during the study period. The mean age (± standard deviation) of patients at presentation was 45.3 ± 19.6 years (range, 3 to 86 years), with a male:female ratio of 1.4:1; 40% of these patients were under age 40 years. Peak incidence was found in the 20 to 29-year and 40 to 49-year age groups. Males were significantly younger than females (P = .00). Poorly differentiated SCC was the most common subtype (47.6%), followed by well-differentiated (32.6%) and moderately differentiated (19.7%) subtypes. The mandibular gingiva was the most commonly affected site (31.8%), followed by the maxillary gingiva (23.3%) and tongue (17.6%). The least commonly affected site was the floor of the mouth. Conclusions: Oral SCC is most common in the mandibular gingiva and in males in our environment, with 40% of cases occurring in patients under age 40 years. The poorly differentiated subtype is the most common histological differentiation. © 2008 American Association of Oral and Maxillofacial Surgeons.
Authors & Co-Authors
Effiom, Olajumoke Ajibola
Nigeria, Lagos
University of Lagos
Adeyemo, Wasiu Lanre
Nigeria, Lagos
University of Lagos
Omitola, Olufemi Gbenga
Nigeria, Lagos
Lagos University Teaching Hospital
Ajayi, Oluseyi Folake
Nigeria, Lagos
University of Lagos
Emmanuel, Mubarak M.
Nigeria, Lagos
Oral Pathology Service
Gbotolorun, Olalekan Micah
Nigeria, Lagos
University of Lagos
Statistics
Citations: 100
Authors: 6
Affiliations: 3
Identifiers
Doi:
10.1016/j.joms.2007.12.025
ISSN:
02782391
Research Areas
Cancer
Health System And Policy
Study Design
Cohort Study
Study Locations
Nigeria
Participants Gender
Male
Female