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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
An anthropomorphic phantom for quantitative evaluation of breast MRI
Medical Physics, Volume 38, No. 2, Year 2011
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Description
Purpose: In this study, the authors aim to develop a physical, tissue-mimicking phantom for quantitative evaluation of breast MRI protocols. The objective of this phantom is to address the need for improved standardization in breast MRI and provide a platform for evaluating the influence of image protocol parameters on lesion detection and discrimination. Quantitative comparisons between patient and phantom image properties are presented. Methods: The phantom is constructed using a mixture of lard and egg whites, resulting in a random structure with separate adipose- and glandular-mimicking components. T1 and T2 relaxation times of the lard and egg components of the phantom were estimated at 1.5 T from inversion recovery and spin-echo scans, respectively, using maximum-likelihood methods. The image structure was examined quantitatively by calculating and comparing spatial covariance matrices of phantom and patient images. A static, enhancing lesion was introduced by creating a hollow mold with stereolithography and filling it with a gadolinium-doped water solution. Results: Measured phantom relaxation values fall within 2 standard errors of human values from the literature and are reasonably stable over 9 months of testing. Comparison of the covariance matrices of phantom and patient data demonstrates that the phantom and patient data have similar image structure. Their covariance matrices are the same to within error bars in the anterior-posterior direction and to within about two error bars in the right-left direction. The signal from the phantom's adipose-mimicking material can be suppressed using active fat-suppression protocols. A static, enhancing lesion can also be included with the ability to change morphology and contrast agent concentration. Conclusions: The authors have constructed a phantom and demonstrated its ability to mimic human breast images in terms of key physical properties that are relevant to breast MRI. This phantom provides a platform for the optimization and standardization of breast MRI imaging protocols for lesion detection and characterization. © 2011 U.S. Government.
Authors & Co-Authors
Freed, Melanie
United States, Rockville
Food and Drug Administration, Center for Devices and Radiological Health
United States, College Park
University of Maryland, College Park
De Zwart, Jacco A.
United States, Bethesda
National Institute of Neurological Disorders and Stroke
Loud, Jennifer T.
United States, Rockville
National Cancer Institute Nci
El-Khouli, Riham H.
United States, Bethesda
National Institutes of Health Nih
United States, Baltimore
Johns Hopkins School of Medicine
Egypt, Ismailia
Faculty of Medicine
Myers, Kyle J.
United States, Rockville
Food and Drug Administration, Center for Devices and Radiological Health
Greene, Mark H.
United States, Rockville
National Cancer Institute Nci
Duyn, Jeff H.
United States, Bethesda
National Institute of Neurological Disorders and Stroke
Badano, Aldo
United States, Rockville
Food and Drug Administration, Center for Devices and Radiological Health
Statistics
Citations: 33
Authors: 8
Affiliations: 7
Identifiers
Doi:
10.1118/1.3533899
ISSN:
00942405
Research Areas
Environmental
Health System And Policy
Study Approach
Quantitative