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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Human rhinovirus C associated with wheezing in hospitalised children in the Middle East
Journal of Clinical Virology, Volume 46, No. 1, Year 2009
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Description
Background: Few studies have investigated the disease burden and genetic diversity of human rhinoviruses (HRVs) in developing countries. Objectives: To assess the burden of HRV in Amman, Jordan, and to characterise clinical differences between HRV groups. Study design: We prospectively studied children <5 years, hospitalised with respiratory symptoms and/or fever in Amman, Jordan. Viruses were identified by real-time reverse transcriptase polymerase chain reaction (RT-PCR). VP4/VP2 gene sequencing was performed on HRV-positive specimens. Results: Of the 728 enrolled children, 266 (37%) tested positive for picornaviruses, 240 of which were HRV. Of the HRV-positive samples, 62 (26%) were of the recently identified group HRVC, 131 (55%) were HRVA and seven (3%) were HRVB. The HRVC strains clustered into at least 19 distinct genotypes. Compared with HRVA-infected children, children with HRVC were more likely to require supplemental oxygen (63% vs. 42%, p = 0.007) and, when co-infections were excluded, were more likely to have wheezing (100% vs. 82%, p = 0.016). Conclusions: There is a significant burden of HRV-associated hospitalisations in young children in Jordan. Infection with the recently identified group HRVC is associated with wheezing and more severe illness. © 2009 Elsevier B.V. All rights reserved.
Authors & Co-Authors
Miller, E. Kathryn
United States, Nashville
Vanderbilt University
Khuri-Bulos, Najwa A.
Jordan, Amman
The University of Jordan
Williams, John V.
United States, Nashville
Vanderbilt University
Shehabi, Asem Ata
Jordan, Amman
The University of Jordan
Faouri, Samir
Unknown Affiliation
Al Jundi, Ihsan
Jordan, Amman
The University of Jordan
Chen, Qingxia
United States, Nashville
Vanderbilt University
Heil, Luke
United States, Nashville
Vanderbilt University
Mohamed, Yassir
United States, Nashville
Vanderbilt University
Morin, Laura Lee
United States, Nashville
Vanderbilt University
Ali, Asad S.
United States, Nashville
Vanderbilt University
Halasa, Natasha B.
United States, Nashville
Vanderbilt University
Statistics
Citations: 131
Authors: 12
Affiliations: 2
Identifiers
Doi:
10.1016/j.jcv.2009.06.007
ISSN:
13866532
Research Areas
Genetics And Genomics
Maternal And Child Health