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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Accelerated surgery versus standard care in hip fracture (HIP ATTACK): an international, randomised, controlled trial
The Lancet, Volume 395, No. 10225, Year 2020
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Description
Background: Observational studies have suggested that accelerated surgery is associated with improved outcomes in patients with a hip fracture. The HIP ATTACK trial assessed whether accelerated surgery could reduce mortality and major complications. Methods: HIP ATTACK was an international, randomised, controlled trial done at 69 hospitals in 17 countries. Patients with a hip fracture that required surgery and were aged 45 years or older were eligible. Research personnel randomly assigned patients (1:1) through a central computerised randomisation system using randomly varying block sizes to either accelerated surgery (goal of surgery within 6 h of diagnosis) or standard care. The coprimary outcomes were mortality and a composite of major complications (ie, mortality and non-fatal myocardial infarction, stroke, venous thromboembolism, sepsis, pneumonia, life-threatening bleeding, and major bleeding) at 90 days after randomisation. Patients, health-care providers, and study staff were aware of treatment assignment, but outcome adjudicators were masked to treatment allocation. Patients were analysed according to the intention-to-treat principle. This study is registered at ClinicalTrials.gov (NCT02027896). Findings: Between March 14, 2014, and May 24, 2019, 27 701 patients were screened, of whom 7780 were eligible. 2970 of these were enrolled and randomly assigned to receive accelerated surgery (n=1487) or standard care (n=1483). The median time from hip fracture diagnosis to surgery was 6 h (IQR 4–9) in the accelerated-surgery group and 24 h (10–42) in the standard-care group (p<0·0001). 140 (9%) patients assigned to accelerated surgery and 154 (10%) assigned to standard care died, with a hazard ratio (HR) of 0·91 (95% CI 0·72 to 1·14) and absolute risk reduction (ARR) of 1% (−1 to 3; p=0·40). Major complications occurred in 321 (22%) patients assigned to accelerated surgery and 331 (22%) assigned to standard care, with an HR of 0·97 (0·83 to 1·13) and an ARR of 1% (−2 to 4; p=0·71). Interpretation: Among patients with a hip fracture, accelerated surgery did not significantly lower the risk of mortality or a composite of major complications compared with standard care. Funding: Canadian Institutes of Health Research. © 2020 Elsevier Ltd
Authors & Co-Authors
Borges, Flávia Kessler
Unknown Affiliation
Bhandari, Mohit
Unknown Affiliation
Guerra-Farfan, Ernesto Melchor
Unknown Affiliation
Patel, Ameen
Unknown Affiliation
Sigamani, Alben
Unknown Affiliation
Umer, Masood
Unknown Affiliation
Tiboni, Maria E.
Unknown Affiliation
Tandon, Vikas
Unknown Affiliation
Tomás Hernández, Jordi
Unknown Affiliation
Teixidor, Jordi Teixidor
Unknown Affiliation
Avram, Victoria Ra
Unknown Affiliation
Winemaker, Mitchell Jeffrey
Unknown Affiliation
Ramokgopa, Mmampapatla Thomas
Unknown Affiliation
Szczeklik, Wojciech
Unknown Affiliation
Landoni, Giovanni
Unknown Affiliation
Wang, Chew Yin
Unknown Affiliation
Neary, John D.D.
Unknown Affiliation
Adili, Anthony F.
Unknown Affiliation
Lawendy, Abdel Rahman
Unknown Affiliation
Balaguer-Castro, Mariano
Unknown Affiliation
Ślȩczka, Paweł
Unknown Affiliation
Jenkinson, Richard J.
Unknown Affiliation
Wood, Gavin C.A.
Unknown Affiliation
Feibel, Robert J.
Unknown Affiliation
Popova, Ekaterine
Unknown Affiliation
Biccard, Bruce Mclure
Unknown Affiliation
Moppett, Iain Keith
Unknown Affiliation
Forget, Patrice
Unknown Affiliation
Landais, Paul
Unknown Affiliation
McGillion, Michael H.
Unknown Affiliation
Vincent, Jessica
Unknown Affiliation
Balasubramanian, Kumar
Unknown Affiliation
Harvey, Valerie
Unknown Affiliation
Pettit, Shirley M.
Unknown Affiliation
Gauthier, Leslie P.
Unknown Affiliation
Gordon, Guyatt H.
Unknown Affiliation
Conen, David
Unknown Affiliation
Garg, Amit X.
Unknown Affiliation
Bangdiwala, Shrikant I.
Unknown Affiliation
Belley-Côté, Émilie Prudence
Unknown Affiliation
Marcucci, Maura
Unknown Affiliation
Lamy, Andre L.
Unknown Affiliation
Whitlock, Richard Paul
Unknown Affiliation
Le Manach, Yannick
Unknown Affiliation
Fergusson, Dean A.
Unknown Affiliation
Yusuf, Salim N.
Unknown Affiliation
Devereaux, Philip James
Unknown Affiliation
Le Polain de Waroux, Bernard
Unknown Affiliation
Lavand'Homme, Patricia M.
Unknown Affiliation
Cornu, Olivier H.
Unknown Affiliation
Yombi, Jean Cyr
Unknown Affiliation
de Beer, Justin V.
Unknown Affiliation
Simpson, Diane L.
Unknown Affiliation
Worster, Andrew S.
Unknown Affiliation
Alvarado, Kim A.
Unknown Affiliation
Gregus, Krysten K.
Unknown Affiliation
Lawrence, Kelly H.
Unknown Affiliation
Leong, Darryl P.
Unknown Affiliation
Joseph, Philip G.
Unknown Affiliation
Magloire, Patrick
Unknown Affiliation
Deheshi, Benjamin M.
Unknown Affiliation
Wood, Thomas J.
Unknown Affiliation
Kearon, Clive
Unknown Affiliation
Cowan, David D.
Unknown Affiliation
Farrell, Janet C.
Unknown Affiliation
MacDonald, Anne Marie
Unknown Affiliation
Wright, Douglas Steven
Unknown Affiliation
Shanthanna, Harsha
Unknown Affiliation
Coughlin, Richard C.
Unknown Affiliation
Wikkerink, Spencer
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Quraishi, Faraaz A.
Unknown Affiliation
Kishta, Waleed E.
Unknown Affiliation
Schemitsch, Emil H.
Unknown Affiliation
Vasarhelyi, Edward M.
Unknown Affiliation
Dresser, George K.
Unknown Affiliation
Choi, Stephen Deanne
Unknown Affiliation
Halman, Samantha
Unknown Affiliation
Ahn, Henry
Unknown Affiliation
Whelan, Daniel Burke
Unknown Affiliation
Jacka, Michael J.
Unknown Affiliation
Dillane, Derek
Unknown Affiliation
Irwin, Michael Garnet
Unknown Affiliation
O'Brien, Peter J.
Unknown Affiliation
Liu, Yang
Unknown Affiliation
Piriou, Vincent
Unknown Affiliation
Friggeri, Arnaud
Unknown Affiliation
Patil, Atul Ashok
Unknown Affiliation
Borate, Madhav Pandurang
Unknown Affiliation
John, Bobby
Unknown Affiliation
Ashraf, Mohammed R.
Unknown Affiliation
Dhillon, Mandeep S. Singh
Unknown Affiliation
Lal, Purushotham
Unknown Affiliation
Rahate, Prashant Vitthal
Unknown Affiliation
Turiel, Maurizio
Unknown Affiliation
Cecconi, Maurizio H.
Unknown Affiliation
Kleinlugtenbelt, Ydo Vincent
Unknown Affiliation
Anjum, Anila
Unknown Affiliation
Rashid, Haroon Ur
Unknown Affiliation
Bokhari, Syedah Saira
Unknown Affiliation
Khan, Abdus Salam
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Umar, Muhammad
Unknown Affiliation
Ashraf, Muhammad Sheharyar
Unknown Affiliation
Firth, Gregory Bodley
Unknown Affiliation
Fourtounas, Maria
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Maqungo, Sithombo
Unknown Affiliation
Flint, Margot
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Nejthardt, Marcin B.
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Chetty, Sean
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Aguado, H. J.
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Vizcaychipi, Marcela Paola
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John, Joby Denise
Unknown Affiliation
Parker, Martyn J.
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Slobogean, Gerard P.
Unknown Affiliation
O'Toole, Robert V.
Unknown Affiliation
Balonov, Konstantin
Unknown Affiliation
Bergese, Sergio Daniel
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Molnar, Sarah H.
Unknown Affiliation
Wells, Jennifer R.
Unknown Affiliation
Ofori, Sandra N.
Unknown Affiliation
Yang, Stephen Su
Unknown Affiliation
Wang, Michael K.
Unknown Affiliation
Duceppe, Emmanuelle
Unknown Affiliation
Spence, Jessica D.
Unknown Affiliation
Vasquez, Javiera P.
Unknown Affiliation
Yung, Terence Ch
Unknown Affiliation
Khan, Jim S.
Unknown Affiliation
Tran, Allen
Unknown Affiliation
Wawrzycka-Adamczyk, Katarzyna
Unknown Affiliation
Biedron, Grzegorz
Unknown Affiliation
Włudarczyk, Anna
Unknown Affiliation
Lefebvre, Marco
Unknown Affiliation
AlWafi, Emad M.
Unknown Affiliation
Mrkobrada, Marko
Unknown Affiliation
Parlow, Simon
Unknown Affiliation
McAlister, Finlay A.
Unknown Affiliation
Wright, James R.C.
Unknown Affiliation
Statistics
Citations: 173
Authors: 136
Identifiers
Doi:
10.1016/S0140-6736(20)30058-1
ISSN:
01406736
Research Areas
Environmental
Health System And Policy
Noncommunicable Diseases