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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Role of HLA-G 14bp deletion/insertion and +3142C>G polymorphisms in the production of sHLA-G molecules in relapsing-remitting multiple sclerosis
Human Immunology, Volume 73, No. 11, Year 2012
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Description
HLA-G is believed to act as an anti-inflammatory molecule in Multiple Sclerosis (MS). The 3' untranslated region of the HLA-G gene is characterized by two polymorphisms, DEL/INS14bp and +3142C>G, which control soluble HLA-G (sHLA-G) production. The influence of these two HLA-G variants on sHLA-G serum and cerebrospinal fluid (CSF) levels was investigated in 69 Relapsing-Remitting MS patients grouped in magnetic resonance imaging (MRI) inactive and active disease. Serum and CSF sHLA-G levels were more elevated in high than in low DEL/INS 14bp and +3142C>G sHLA-G producers and were different among the various combined HLA-G genotypes in both MRI inactive and active diseases. The highest and the lowest sHLA-G values were identified in MS patients with C/C,DEL/DEL and G/G,INS/INS genotypes, respectively. Our preliminary findings suggest that serum and CSF sHLA-G levels in MS could be influenced by HLA-G polymorphisms irrespective of the inflammatory microenvironment. © 2012 American Society for Histocompatibility and Immunogenetics.
Authors & Co-Authors
Rizzo, Roberta
Italy, Ferrara
University of Ferrara
Bortolotti, Daria
Italy, Ferrara
University of Ferrara
Fredj, Nadia Ben
Tunisia, Monastir
Université de Monastir
Rotola, Antonella
Italy, Ferrara
University of Ferrara
Cura, Franscesca
Italy, Ferrara
University of Ferrara
Castellazzi, Massimiliano
Italy, Ferrara
University of Ferrara
Tamborino, Carmine
Italy, Ferrara
University of Ferrara
Seraceni, Silva
Italy, Ferrara
University of Ferrara
Baldi, Eleonora
Italy, Cona
Azienda Ospedaliero-universitaria Di Ferrara
Melchiorri, Loredana
Italy, Ferrara
University of Ferrara
Tola, Maria Rosaria
Italy, Cona
Azienda Ospedaliero-universitaria Di Ferrara
Granierí, Enrico
Italy, Ferrara
University of Ferrara
Baricordi, Olavio R.
Italy, Ferrara
University of Ferrara
Fainardi, Enrico
Italy, Cona
Azienda Ospedaliero-universitaria Di Ferrara
Statistics
Citations: 58
Authors: 14
Affiliations: 3
Identifiers
Doi:
10.1016/j.humimm.2012.08.005
ISSN:
01988859
e-ISSN:
18791166
Research Areas
Genetics And Genomics