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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
general
Interaction between the nasal microbiota and S. pneumoniae in the context of live-attenuated influenza vaccine
Nature Communications, Volume 10, No. 1, Article 2981, Year 2019
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Description
Streptococcus pneumoniae is the main bacterial pathogen involved in pneumonia. Pneumococcal acquisition and colonization density is probably affected by viral co-infections, the local microbiome composition and mucosal immunity. Here, we report the interactions between live-attenuated influenza vaccine (LAIV), successive pneumococcal challenge, and the healthy adult nasal microbiota and mucosal immunity using an experimental human challenge model. Nasal microbiota profiles at baseline are associated with consecutive pneumococcal carriage outcome (non-carrier, low-dense and high-dense pneumococcal carriage), independent of LAIV co-administration. Corynebacterium/Dolosigranulum-dominated profiles are associated with low-density colonization. Lowest rates of natural viral co-infection at baseline and post-LAIV influenza replication are detected in the low-density carriers. Also, we detected the fewest microbiota perturbations and mucosal cytokine responses in the low-density carriers compared to non-carriers or high-density carriers. These results indicate that the complete respiratory ecosystem affects pneumococcal behaviour following challenge, with low-density carriage representing the most stable ecological state. © 2019, The Author(s).
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC6611866/bin/41467_2019_10814_MOESM1_ESM.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC6611866/bin/41467_2019_10814_MOESM2_ESM.pdf
Authors & Co-Authors
de Steenhuijsen Piters, Wouter A.A.
Netherlands, Utrecht
Wilhelmina Kinderziekenhuis
Netherlands, Utrecht
University Medical Center Utrecht
United Kingdom, Edinburgh
University of Edinburgh, College of Medicine and Veterinary Medicine
Jochems, Simon P.
United Kingdom, Liverpool
Liverpool School of Tropical Medicine
Mitsi, Elena
United Kingdom, Liverpool
Liverpool School of Tropical Medicine
Rylance, Jamie
United Kingdom, Liverpool
Liverpool School of Tropical Medicine
Pojar, Sherin
United Kingdom, Liverpool
Liverpool School of Tropical Medicine
Nikolaou, Elissavet
United Kingdom, Liverpool
Liverpool School of Tropical Medicine
German, Esther L.
United Kingdom, Liverpool
Liverpool School of Tropical Medicine
Holloway, Mark
United Kingdom, Liverpool
Liverpool School of Tropical Medicine
Carniel, Beatriz F.
United Kingdom, Liverpool
Liverpool School of Tropical Medicine
Chu, Mei Ling J.N.
Netherlands, Utrecht
Wilhelmina Kinderziekenhuis
Netherlands, Utrecht
University Medical Center Utrecht
Sanders, Elisabeth A.M.(Elisabeth)
Netherlands, Utrecht
Wilhelmina Kinderziekenhuis
Ferreira, Daniela Mulari
United Kingdom, Liverpool
Liverpool School of Tropical Medicine
Bogaert, Debby (Debby)
Netherlands, Utrecht
Wilhelmina Kinderziekenhuis
Netherlands, Utrecht
University Medical Center Utrecht
United Kingdom, Edinburgh
University of Edinburgh, College of Medicine and Veterinary Medicine
Statistics
Citations: 47
Authors: 13
Affiliations: 4
Identifiers
Doi:
10.1038/s41467-019-10814-9
ISSN:
20411723