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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Reduced resting skeletal muscle protein synthesis is rescued by resistance exercise and protein ingestion following short-term energy deficit
American Journal of Physiology - Endocrinology and Metabolism, Volume 306, No. 8, Year 2014
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Description
The myofibrillar protein synthesis (MPS) response to resistance exercise (REX) and protein ingestion during energy deficit (ED) is unknown. In young men (n = 8) and women (n = 7), we determined protein signaling and resting postabsorptive MPS during energy balance [EB; 45 kcal·kg fat-free mass (FFM)-1·day-1] and after 5 days of ED (30 kcal·kg FFM-1·day-1) as well as MPS while in ED after acute REX in the fasted state and with the ingestion of whey protein (15 and 30 g). Postabsorptive rates of MPS were 27% lower in ED than EB (P < 0.001), but REX stimulated MPS to rates equal to EB. Ingestion of 15 and 30 g of protein after REX in ED increased MPS ~16 and ~34% above resting EB (P < 0.02). p70 S6K Thr389 phosphorylation increased above EB only with combined exercise and protein intake (~2-7 fold, P < 0.05). In conclusion, short-term ED reduces postabsorptive MPS; however, a bout of REX in ED restores MPS to values observed at rest in EB. The ingestion of protein after REX further increases MPS above resting EB in a dose-dependent manner. We conclude that combining REX with increased protein availability after exercise enhances rates of skeletal muscle protein synthesis during short-term ED and could in the long term preserve muscle mass. © 2014 American Physiological Society.
Authors & Co-Authors
Burke, Louise M.
Australia, Canberra
Australian Institute of Sport
Stellingwerff, Trent
Canada, Victoria
Canadian Sport Institute Pacific Institut Canadien du Sport Pacifique
Hawley, John A.
Australia, Melbourne
Rmit University
Statistics
Citations: 148
Authors: 3
Affiliations: 5
Identifiers
Doi:
10.1152/ajpendo.00590.2013
ISSN:
01931849
Participants Gender
Male
Female