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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
The potential impact of expanding antiretroviral therapy and combination prevention in Vietnam: Towards elimination of HIV transmission
Journal of Acquired Immune Deficiency Syndromes, Volume 63, No. 5, Year 2013
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Description
Background: Few studies have assessed the effects of antiretroviral therapy (ART) to prevent HIV transmission in Asian HIV epidemics. Vietnam has a concentrated HIV epidemic with the highest prevalence among people who inject drugs. We investigated the impact of expanded HIV testing and counseling (HTC) and early ART, combined with other prevention interventions on HIV transmission. Methods: A deterministic mathematical model was developed using HIV prevalence trends in Can Tho province, Vietnam. Scenarios included offering periodic HTC and immediate ART with and without targeting subpopulations and examining combined strategies with methadone maintenance therapy and condom use. Results: From 2011 to 2050, maintaining current interventions will incur an estimated 18,115 new HIV infections and will cost US $22.1 million (reference scenario). Annual HTC and immediate treatment, if offered to all adults, will reduce new HIV infections by 14,513 (80%) and will cost US $76.9 million. Annual HTC and immediate treatment offered only to people who inject drugs will reduce new infections by 13,578 (75%) and will cost only US $23.6 million. Annual HTC and immediate treatment for key populations, combined with scale-up of methadone maintenance therapy and condom use, will reduce new infections by 14,723 (81%) with similar costs (US $22.7 million). This combination prevention scenario will reduce the incidence to less than 1 per 100,000 in 14 years and will result in a relative cost saving after 19 years. Conclusions: Targeted periodic HTC and immediate ART combined with other interventions is cost-effective and could lead to potential elimination of HIV in Can Tho. Copyright © 2013 by Lippincott Williams & Wilkins.
Authors & Co-Authors
Kato, Masaya
Switzerland, Geneva
Organisation Mondiale de la Santé
Granich, Reuben M.
Switzerland, Geneva
Organisation Mondiale de la Santé
Bui, Duong Duc
Viet Nam, Hanoi
Ministry of Health Vitenam
Tran, Hoang V.
United States, Boston
Partners in Health
Nadol, Patrick
Viet Nam, Hanoi
Centers for Disease Control - Vietnam Office
Jacka, David
Switzerland, Geneva
Organisation Mondiale de la Santé
Sabin, Keith M.
Switzerland, Geneva
Organisation Mondiale de la Santé
Suthar, Amitabh Bipin
Switzerland, Geneva
Organisation Mondiale de la Santé
Mesquita, Fábio C.L.
Switzerland, Geneva
Organisation Mondiale de la Santé
Lo, Ying Ru Jacqueline
Switzerland, Geneva
Organisation Mondiale de la Santé
Williams, Brian Gerard
South Africa, Stellenbosch
Stellenbosch University
Statistics
Citations: 75
Authors: 11
Affiliations: 5
Identifiers
Doi:
10.1097/QAI.0b013e31829b535b
ISSN:
15254135
Research Areas
Infectious Diseases
Study Design
Cross Sectional Study
Cohort Study