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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
Antioxidant and free radical-scavenging properties of three flavonoids isolated from the leaves of Rhamnus alaternus L. (Rhamnaceae) : A structure-activity relationship study
Food Chemistry, Volume 116, No. 1, Year 2009
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Description
Fractionation of the methanolic and total oligomer flavonoid enriched extracts from Rhamnus alaternus leaves resulted in the isolation of three flavonoids: kaempferol 3-O-isorhamninoside (1), rhamnocitrin-3-O-isorhamninoside (2) and rhamnetin-3-O-isorhamninoside (3), along with apigenin, kaempferol and quercetin. The structures were determined using data obtained from FAB-MS, 1H and 13C NMR spectra, as well as by various correlation experiments (COSY, HMQC and HMBC). The antioxidant activities of the isolated compounds were evaluated by measuring their ability to scavenge the DPPH radical and superoxide anions, to inhibit H2O2-induced lipid peroxidation in human K562 cells, and to inhibit xanthine oxidase activity. Compound 3 was a strong scavenger of DPPH{radical dot} and superoxide anion radicals, and a potent inhibitor of H2O2-induced lipid peroxidation, with respective IC50 values of 1.5, 35 and 106 μg/ml, whereas compound 1 showed the better activity in the inhibition of xanthine oxidase activity with an IC50 value of 18 μg/ml, showing some structure-activity relationships. © 2009 Elsevier Ltd. All rights reserved.
Authors & Co-Authors
Ben Ammar, Rebai
Tunisia, Monastir
Faculté de Pharmacie de Monastir
Bhouri, Wissem
Tunisia, Monastir
Faculté de Pharmacie de Monastir
Ben-Sghaier, Mohamed
Tunisia, Monastir
Faculté de Pharmacie de Monastir
Boubaker, Jihed
Tunisia, Monastir
Faculté de Pharmacie de Monastir
Skandrani, Inès
Tunisia, Monastir
Faculté de Pharmacie de Monastir
Neffati, Aïcha
Tunisia, Monastir
Faculté de Pharmacie de Monastir
Bouhlel, Inès
Tunisia, Monastir
Faculté de Pharmacie de Monastir
Kilani, Soumaya
Tunisia, Monastir
Faculté de Pharmacie de Monastir
Mariotte, Anne Marie
France, Grenoble
Département de Pharmacochimie Moléculaire Dpm
Chékir-Ghédira, Leila
Tunisia, Monastir
Faculté de Pharmacie de Monastir
Dijoux-Franca, Marie Geneviève
France, Villeurbanne
Ecologie Microbienne Lem
Ghédira, Kamel
Tunisia, Monastir
Faculté de Pharmacie de Monastir
Statistics
Citations: 129
Authors: 12
Affiliations: 3
Identifiers
Doi:
10.1016/j.foodchem.2009.02.043
ISSN:
03088146