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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Recombination, decreased host specificity and increased mobility may have driven the emergence of maize streak virus as an agricultural pathogen
Journal of General Virology, Volume 89, No. 9, Year 2008
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Description
Maize streak virus (MSV; family Geminiviridae, genus Mastrevirus), the causal agent of maize streak disease, ranks amongst the most serious biological threats to food security in subSaharan Africa. Although five distinct MSV strains have been currently described, only one of these - MSV-A - causes severe disease in maize. Due primarily to their not being an obvious threat to agriculture, very little is known about the 'grass-adapted' MSV strains, MSV-B, -C, -D and -E. Since comparing the genetic diversities, geographical distributions and natural host ranges of MSV-A with the other MSV strains could provide valuable information on the epidemiology, evolution and emergence of MSV-A, we carried out a phylogeographical analysis of MSVs found in uncultivated indigenous African grasses. Amongst the 83 new MSV genomes presented here, we report the discovery of six new MSV strains (MSV-F to -K). The non-random recombination breakpoint distributions detectable with these and other available mastrevirus sequences partially mirror those seen in begomoviruses, implying that the forces shaping these breakpoint patterns have been largely conserved since the earliest geminivirus ancestors. We present evidence that the ancestor of all MSV-A variants was the recombinant progeny of ancestral MSV-B and MSV-G/-F variants. While it remains unknown whether recombination influenced the emergence of MSV-A in maize, our discovery that MSV-A variants may both move between and become established in different regions of Africa with greater ease, and infect more grass species than other MSV strains, goes some way towards explaining why MSV-A is such a successful maize pathogen. © 2008 SGM.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC2886952/bin/supp_89_9_2063__index.html
https://efashare.b-cdn.net/share/pmc/articles/PMC2886952/bin/supp_89_9_2063__1.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC2886952/bin/supp_89_9_2063__Supplementary_Table1.xls
https://efashare.b-cdn.net/share/pmc/articles/PMC2886952/bin/supp_89_9_2063__Supplemnetary_Table3.xls
https://efashare.b-cdn.net/share/pmc/articles/PMC2886952/bin/supp_89_9_2063__RAR.rdp
Authors & Co-Authors
Varsani, Arvind
South Africa, Cape Town
University of Cape Town
Shepherd, Dionne Natalie
South Africa, Cape Town
University of Cape Town
Monjane, Adérito Luis
South Africa, Cape Town
University of Cape Town
Owor, Betty Elizabeth
South Africa, Cape Town
University of Cape Town
Erdmann, Julia B.
South Africa, Cape Town
University of Cape Town
Germany, Stuttgart
Universität Stuttgart
Rybicki, Edward P.
South Africa, Cape Town
University of Cape Town
Peterschmitt, Michel
France, Paris
Cirad
Briddon, Rob William
Pakistan, Faisalabad
National Institute for Biotechnology and Genetic Engineering Pakistan
Markham, Peter G.
United Kingdom, Norwich
John Innes Centre
Oluwafemi, Sunday
Nigeria, Iwo
Bowen University
Windram, Oliver P.F.
United Kingdom, Coventry
University of Warwick
Lefeuvre, Pierre F.
France, Saint-denis
Université de la Réunion
Lett, Jean Michel
France, Saint-denis
Université de la Réunion
Martin, Darren Patrick
South Africa, Cape Town
University of Cape Town
Statistics
Citations: 140
Authors: 14
Affiliations: 8
Identifiers
Doi:
10.1099/vir.0.2008/003590-0
ISSN:
00221317
Research Areas
Food Security
Genetics And Genomics