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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
A human phase I/IIa malaria challenge trial of a polyprotein malaria vaccine
Vaccine, Volume 29, No. 43, Year 2011
Notification
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Description
We examined the safety, immunogenicity and efficacy of a prime-boost vaccination regime involving two poxvirus malaria subunit vaccines, FP9-PP and MVA-PP, expressing the same polyprotein consisting of six pre-erythrocytic antigens from Plasmodium falciparum. Following safety assessment of single doses, 15 volunteers received a heterologous prime-boost vaccination regime and underwent malaria sporozoite challenge. The vaccines were safe but interferon-γ ELISPOT responses were low compared to other poxvirus vectors, despite targeting multiple antigens. There was no vaccine efficacy as measured by delay in time to parasitaemia. A number of possible explanations are discussed, including the very large insert size of the polyprotein transgene. © 2011 Elsevier Ltd.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC3195259/bin/mmc1.pdf
Authors & Co-Authors
Porter, David W.
United Kingdom, Oxford
Churchill Hospital
Thompson, Fiona M.
United Kingdom, Oxford
Churchill Hospital
Berthoud, Tamara Katherine
United Kingdom, Oxford
University of Oxford
Hutchings, Claire L.
United Kingdom, Oxford
University of Oxford
Andrews, Laura
United Kingdom, Oxford
University of Oxford
Biswas, Sumi
United Kingdom, Oxford
University of Oxford
Poulton, Ian D.
United Kingdom, Oxford
Churchill Hospital
Prieur, Eric
United Kingdom, Oxford
University of Oxford
France, Paris
Institut Pasteur, Paris
Correa, Simon
Gambia, Banjul
Medical Research Council Laboratories Gambia
Rowland, Rosalind
United Kingdom, Oxford
Churchill Hospital
Lang, Trudie A.
United Kingdom, Oxford
Churchill Hospital
Williams, Jackie L.
United States, Silver Spring
Walter Reed Army Institute of Research
Gilbert, Sarah C.
United Kingdom, Oxford
University of Oxford
Sinden, Robert E.
United Kingdom, London
Imperial College London
Todryk, Stephen M.
United Kingdom, Oxford
University of Oxford
United Kingdom, Newcastle
University of Northumbria
Hill, Adrian V. S.
United Kingdom, Oxford
Churchill Hospital
United Kingdom, Oxford
University of Oxford
Statistics
Citations: 51
Authors: 16
Affiliations: 7
Identifiers
Doi:
10.1016/j.vaccine.2011.03.083
ISSN:
0264410X
e-ISSN:
18732518
Research Areas
Infectious Diseases