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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
Potential antiradical and alpha-glucosidase inhibitors from Ecklonia maxima (Osbeck) Papenfuss
Food Chemistry, Volume 141, No. 2, Year 2013
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Description
Alpha-glucosidase inhibitors play a potential role in the treatment of type 2 diabetes by delaying glucose absorption in the small intestine. Ecklonia maxima, a brown alga which grows abundantly on the west coast of South Africa, is used to produce alginate, animal feed, nutritional supplements and fertilizer. The crude aqueous methanol extract, four solvent fractions and three phlorotannins: 1,3,5-trihydroxybenezene (phloroglucinol) (1), dibenzo [1,4] dioxine-2,4,7,9-tetraol (2) and hexahydroxyphenoxydibenzo [1,4] dioxine (eckol) (3) isolated from E. maxima were evaluated for antiradical and alpha-glucosidase inhibitory activities. All the phlorotannins tested had strong antioxidant activities on DPPH free radicals with EC50 values ranging from 0.008 to 0.128 μM. Compounds 2 and 3 demonstrated stronger antioxidant activity and an alpha-glucosidase inhibitory property than positive controls. These results suggest that E. maxima could be a natural source of potent antioxidants and alpha-glucosidase inhibitors. This study could facilitate effective utilization of E. maxima as an oral antidiabetic drug or functional food ingredient with a promising role in the formulation of medicines and nutrition supplements. © 2013 Elsevier Ltd.
Authors & Co-Authors
Rengasamy, Kannan R.R.
South Africa, Durban
University of Kwazulu-natal
Aderogba, Mutalib A.
South Africa, Durban
University of Kwazulu-natal
Amoo, Stephen Oluwaseun
South Africa, Durban
University of Kwazulu-natal
Stirk, Wendy Ann
South Africa, Durban
University of Kwazulu-natal
van Staden, Johannes V.
South Africa, Durban
University of Kwazulu-natal
Statistics
Citations: 99
Authors: 5
Affiliations: 1
Identifiers
Doi:
10.1016/j.foodchem.2013.04.019
ISSN:
03088146
e-ISSN:
18737072
Research Areas
Food Security
Health System And Policy
Noncommunicable Diseases
Study Locations
South Africa