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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis
Nature Genetics, Volume 42, No. 7, Year 2010
Notification
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Description
By combining genome-wide association data from 8,130 individuals with type 2 diabetes (T2D) and 38,987 controls of European descent and following up previously unidentified meta-analysis signals in a further 34,412 cases and 59,925 controls, we identified 12 new T2D association signals with combined P 5 × 10 8. These include a second independent signal at the KCNQ1 locus; the first report, to our knowledge, of an X-chromosomal association (near DUSP9); and a further instance of overlap between loci implicated in monogenic and multifactorial forms of diabetes (at HNF1A). The identified loci affect both beta-cell function and insulin action, and, overall, T2D association signals show evidence of enrichment for genes involved in cell cycle regulation. We also show that a high proportion of T2D susceptibility loci harbor independent association signals influencing apparently unrelated complex traits. © 2010 Nature America, Inc. All rights reserved.
Authors & Co-Authors
Voight, Benjamin F.
United States, Cambridge
Broad Institute
United States, Boston
Massachusetts General Hospital
United States, Boston
Harvard Medical School
Scott, Laura J.
United States, Ann Arbor
University of Michigan, Ann Arbor
Steinthórsdóttir, Valgerdur
Iceland, Reykjavik
Decode Genetics
Morris, Andrew Paul
United Kingdom, Oxford
University of Oxford
Dina, Christian
France, Lille
Université de Lille
France, Paris
Inserm
Welch, Ryan P.
United States, Ann Arbor
University of Michigan, Ann Arbor
Zeggini, Eleftheria
United Kingdom, Oxford
University of Oxford
United Kingdom, Hinxton
Wellcome Sanger Institute
Aulchenko, Yurii S.
Netherlands, Rotterdam
Erasmus Mc
Thorleifsson, Gudmar
Iceland, Reykjavik
Decode Genetics
Ferreira, Teresa
United Kingdom, Oxford
University of Oxford
Grallert, Harald
Germany, Oberschleissheim
Helmholtz Center Munich German Research Center for Environmental Health
Germany, Munich
Ludwig-maximilians-universität München
Amin, Najaf A.
Netherlands, Rotterdam
Erasmus Mc
Willer, Cristen J.
United States, Ann Arbor
University of Michigan, Ann Arbor
Raychaudhuri, Soumya
United States, Cambridge
Broad Institute
United States, Boston
Massachusetts General Hospital
United States, Boston
Harvard Medical School
McCarroll, Steven A.
United States, Cambridge
Broad Institute
United States, Boston
Harvard Medical School
Langenberg, Claudia C.
United Kingdom, Cambridge
Wellcome-mrc Institute of Metabolic Science
Hofmann, Oliver M.
United States, Boston
Harvard T.h. Chan School of Public Health
Dupuis, Josèe
United States, Boston
School of Public Health
United States, Framingham
Framingham Heart Study
Qi, Llu
United States, Boston
Harvard T.h. Chan School of Public Health
United States, Boston
Harvard Medical School
Segrè, Ayellet V.
United States, Cambridge
Broad Institute
United States, Boston
Massachusetts General Hospital
United States, Boston
Harvard Medical School
Navarro, Pau
United Kingdom, Edinburgh
Mrc Human Genetics Unit
Balkau, Beverley J.
France, Paris
Inserm
France, Villejuif
Centre de Recherche en Épidémiologie et Santé Des Populations
Benediktsson, Rafn
Iceland, Reykjavik
Landspitali - the National University Hospital of Iceland
Iceland, Kopavogur
Icelandic Heart Association
Bennett, Amanda J.
United Kingdom, Oxford
University of Oxford
Boerwinkle, Eric A.
United States, Houston
University of Texas Health Science Center at Houston
Bonnycastle, Lori L.C.
United States, Bethesda
National Institutes of Health Nih
Bengtsson-Boström, Kristina
Unknown Affiliation
Bumpstead, Suzannah J.
United Kingdom, Hinxton
Wellcome Sanger Institute
Burtt, Nöel P.
United States, Cambridge
Broad Institute
Charpentier, Guillaume
France, Corbeil-essonnes
Centre Hospitalier Sud-francilien
Chines, Peter S.
United States, Bethesda
National Institutes of Health Nih
Cornelis, Marylin C.
United States, Boston
Harvard Medical School
Couper, David J.
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Doney, Alex S.F.
United Kingdom, Dundee
Ninewells Hospital
Erdos, Michael R.
United States, Bethesda
National Institutes of Health Nih
Fox, Caroline S.
United States, Framingham
Framingham Heart Study
United States, Boston
Harvard Medical School
Franklin, Christopher S.
United Kingdom, Edinburgh
The University of Edinburgh
Gieger, Christian
Germany, Oberschleissheim
Helmholtz Center Munich German Research Center for Environmental Health
Grarup, Niels
Denmark, Gentofte
Hagedorn Research Institute
Griffin, Simon J.
United Kingdom, Cambridge
Wellcome-mrc Institute of Metabolic Science
Groves, Christopher James
United Kingdom, Oxford
University of Oxford
Hadjadj, Samy
France, Paris
Inserm
Hassanali, Neelam
United Kingdom, Oxford
University of Oxford
Herder, Christian
Germany, Dusseldorf
Deutsches Diabetes-zentrum
Isomaa, Bo A.
Finland, Helsinki
Folkhälsan
Jackson, Anne U.
United States, Ann Arbor
University of Michigan, Ann Arbor
Johnson, Paul R.V.
United Kingdom, Oxford
University of Oxford
Jörgensen, Torben J.
Denmark, Glostrup
Amtssygehuset I Glostrup
Denmark, Copenhagen
Københavns Universitet
Kao, Wenhong Linda
United States, Baltimore
Johns Hopkins University
Klopp, Norman
Germany, Oberschleissheim
Helmholtz Center Munich German Research Center for Environmental Health
Kong, Augustine
Iceland, Reykjavik
Decode Genetics
Kraft, Peter L.
United States, Boston
Harvard T.h. Chan School of Public Health
Kuusisto, Johanna K.
Finland, Kuopio
Kuopio University Hospital
Li, Man
United States, Baltimore
Johns Hopkins University
Lindgren, Cecilia M.
United Kingdom, Oxford
University of Oxford
Lyssenko, Valeriya
Sweden, Lund
Skånes Universitetssjukhus
Marre, Michel
France, Paris
Ap-hp Assistance Publique - Hopitaux de Paris
France, Paris
Université Paris Cité
Meitinger, Thomas A.
Germany, Oberschleissheim
Helmholtz Center Munich German Research Center for Environmental Health
Germany, Munich
Technische Universität München
Midthjell, Kristian
Norway, Trondheim
Norges Teknisk-naturvitenskapelige Universitet
Morken, Mario A.
United States, Bethesda
National Institutes of Health Nih
Narisu, Narisu
United States, Bethesda
National Institutes of Health Nih
Nilsson, Peter M.
Sweden, Lund
Skånes Universitetssjukhus
Owen, Katharine R.
United Kingdom, Oxford
University of Oxford
Payne, Felicity
United Kingdom, Hinxton
Wellcome Sanger Institute
Perry, John R.B.
United Kingdom, Plymouth
Peninsula Medical School, Universities of Exeter and Plymouth
United Kingdom, Exeter
University of Exeter
Petersen, Ann Kristin
Germany, Oberschleissheim
Helmholtz Center Munich German Research Center for Environmental Health
Proença, Christine
France, Lille
Université de Lille
Prokopenko, Inga I.
United Kingdom, Oxford
University of Oxford
Rathmann, Wolfgang G.
Germany, Dusseldorf
Deutsches Diabetes-zentrum
Rayner, Nigel William
United Kingdom, Oxford
University of Oxford
Robertson, Neil R.
United Kingdom, Oxford
University of Oxford
Rocheleau, Ghislain
Canada, Montreal
Université Mcgill
Roden, M. W.
Germany, Dusseldorf
Deutsches Diabetes-zentrum
Germany, Dusseldorf
Heinrich-heine-universität Düsseldorf
Meitinger, Thomas
United States, Cambridge
Broad Institute
United States, Boston
Massachusetts General Hospital
United States, Boston
Harvard Medical School
Shields, Beverley M.
United Kingdom, Plymouth
Peninsula Medical School, Universities of Exeter and Plymouth
United Kingdom, Exeter
University of Exeter
Sparsø, Thomas
Denmark, Gentofte
Hagedorn Research Institute
Strassburger, Klaus
Germany, Dusseldorf
Deutsches Diabetes-zentrum
Stringham, Heather M.
United States, Ann Arbor
University of Michigan, Ann Arbor
Sun, Qi
United States, Boston
Harvard T.h. Chan School of Public Health
Swift, Amy J.
United States, Bethesda
National Institutes of Health Nih
Thorand, Barbara
Germany, Oberschleissheim
Helmholtz Center Munich German Research Center for Environmental Health
Tuomi, Tiinamaija
Finland, Helsinki
Folkhälsan
Finland, Helsinki
Helsingin Yliopisto
van Dam, Robertus Martinus
United States, Boston
Harvard Medical School
van Haeften, Timon W.
Netherlands, Utrecht
University Medical Center Utrecht
van Vliet-Ostaptchouk, Jana V.
Netherlands, Groningen
Rijksuniversiteit Groningen
Walters, G. Bragi
Iceland, Reykjavik
Decode Genetics
Weedon, Michael N.
United Kingdom, Plymouth
Peninsula Medical School, Universities of Exeter and Plymouth
United Kingdom, Exeter
University of Exeter
Wijmenga, Cisca
Netherlands, Groningen
Rijksuniversiteit Groningen
Witteman, Jacqueline C.M.
Netherlands, Rotterdam
Erasmus Mc
Bergman, Richard N.
United States, Los Angeles
Keck School of Medicine of Usc
Cauchi, Stéphane S.
France, Lille
Université de Lille
Collins, Francis S.
United States, Bethesda
National Institutes of Health Nih
Gloyn, Anna L.
United Kingdom, Oxford
University of Oxford
Gyllensten, Ulf B.
Sweden, Uppsala
Uppsala Universitet
Hansen, Torben Frøstrup
Denmark, Gentofte
Hagedorn Research Institute
Denmark, Odense
Syddansk Universitet
Hide, Winston A.
United States, Boston
Harvard T.h. Chan School of Public Health
Hitman, Graham A.
United Kingdom, London
Queen Mary University of London
Hofman, Albert
Netherlands, Rotterdam
Erasmus Mc
Hunter, D. J.
United States, Boston
Harvard T.h. Chan School of Public Health
Hveem, Kristian
Norway, Trondheim
Norges Teknisk-naturvitenskapelige Universitet
Laakso, M. M.
Finland, Kuopio
Kuopio University Hospital
Mohlke, Karen
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Morris, Andrew D.
United Kingdom, Dundee
Ninewells Hospital
Palmer, Colin Neil Alexander
United Kingdom, Dundee
Ninewells Hospital
Pramstaller, Peter P.
Italy, Bolzano
Eurac Research
Rudan, Igor
United Kingdom, Edinburgh
The University of Edinburgh
Croatia, Split
School of Medicine, University of Split
Croatia, Zagreb
Klinički Bolnički Centar Sestre Milosrdnice
Sijbrands, Eric J.G.
Netherlands, Rotterdam
Erasmus Mc
Tuomilehto, Jaakko O.I.
Finland, Helsinki
Helsingin Yliopisto
Finland, Seinajoki
South Ostrobothnia Central Hospital
Spain, Madrid
Hospital Universitario la Paz
Uitterlinden, André G.
Netherlands, Rotterdam
Erasmus Mc
Walker, Mark A.
United Kingdom, Newcastle
Newcastle University
Wareham, Nicholas J.
United Kingdom, Cambridge
Wellcome-mrc Institute of Metabolic Science
Watanabe, Richard M.
United States, Los Angeles
Keck School of Medicine of Usc
United States, Los Angeles
University of Southern California
Abecasis, Gonçalo R.
United States, Ann Arbor
University of Michigan, Ann Arbor
Böehm, Bernhard Otto
Germany, Ulm
Universität Ulm
Campbell, Harry
United Kingdom, Edinburgh
The University of Edinburgh
Daly, Mark J.
United States, Cambridge
Broad Institute
United States, Boston
Massachusetts General Hospital
Hattersley, Andrew T.
United Kingdom, Plymouth
Peninsula Medical School, Universities of Exeter and Plymouth
United Kingdom, Exeter
University of Exeter
Hu, Frank B.
United States, Boston
Harvard T.h. Chan School of Public Health
United States, Boston
Harvard Medical School
Meigs, James B.
United States, Boston
Harvard Medical School
United States, Boston
Massachusetts General Hospital
Pankow, Jim S.
United States, Minneapolis
University of Minnesota Twin Cities
Pedersen, Oluf Borbye
Denmark, Gentofte
Hagedorn Research Institute
Denmark, Copenhagen
Københavns Universitet
Denmark, Aarhus
Aarhus Universitet
Wichmann, Heinz-Erich Erich
Germany, Oberschleissheim
Helmholtz Center Munich German Research Center for Environmental Health
Germany, Munich
Ludwig-maximilians-universität München
Germany, Munich
Klinikum Der Universität München
Barroso, Inês E.
United Kingdom, Hinxton
Wellcome Sanger Institute
Florez, Jose C.
United States, Cambridge
Broad Institute
United States, Boston
Massachusetts General Hospital
United States, Boston
Harvard Medical School
Frayling, Tim M.
United Kingdom, Plymouth
Peninsula Medical School, Universities of Exeter and Plymouth
United Kingdom, Exeter
University of Exeter
Groop, Leif C.
Sweden, Lund
Skånes Universitetssjukhus
Finland, Helsinki
Helsingin Yliopisto
Sladek, Robert S.
Canada, Montreal
Université Mcgill
Thorsteinsdottir, Unnur Arna
Iceland, Reykjavik
Decode Genetics
Iceland, Reykjavik
Haskoli Islands
Wilson, James F.
United Kingdom, Edinburgh
The University of Edinburgh
Illig, Thomas
Germany, Oberschleissheim
Helmholtz Center Munich German Research Center for Environmental Health
Froguel, Philippe
United States, Boston
Harvard Medical School
United Kingdom, London
Imperial College London
van Duijn, Cornelia M.
Netherlands, Rotterdam
Erasmus Mc
Stefánsson, Kári
Iceland, Reykjavik
Decode Genetics
Iceland, Reykjavik
Haskoli Islands
Altshuler, David M.
United States, Cambridge
Broad Institute
United States, Boston
Massachusetts General Hospital
United States, Boston
Harvard Medical School
Boehnke, Michael L.
United States, Ann Arbor
University of Michigan, Ann Arbor
McCarthy, Mark I.
United Kingdom, Oxford
University of Oxford
United Kingdom, Royston
National Institute for Health and Care Research
Statistics
Citations: 1,479
Authors: 136
Affiliations: 68
Identifiers
Doi:
10.1038/ng.609
ISSN:
15461718
Research Areas
Noncommunicable Diseases
Study Approach
Systematic review