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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
10-acetylirciformonin B, A sponge furanoterpenoid, induces dna damage and apoptosis in leukemia cells
Molecules, Volume 17, No. 10, Year 2012
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Description
10-Acetylirciformonin B, a furanoterpenoid derived from irciformonin B found in a marine sponge, has been reported to possess potent cytotoxic activity against several cancer cell lines. However, the mechanism of its apoptotic activity against human leukemia cells has never been reported. The purpose of this study was to investigate the cytotoxic effects of 10-acetylirciformonin B and its possible mechanism of action against leukemia HL 60 cells. We found that 10-acetylirciformonin B decreased cell viability through the inhibition of cell growth as well as the induction of DNA damage and apoptosis in a dose-dependent manner. The induction of DNA damage was mediated by the increase of p-CHK2 and γ-H2A.X, which was suggested from the increase of tail movement in the neutral Comet assay. Induction of apoptosis was mediated with the increase in caspases 8, 9 and 3 activation as well as PARP cleavage. In summary, our resultsindicate that 10-acetylirciformonin B treatment causes apoptosis in leukaemia cells; probably through a caspase-dependent regulatory pathway. © 2012 by the authors; licensee MDPI, Basel, Switzerland.
Authors & Co-Authors
Su, Juihsin
Taiwan, Shoufeng
National Dong Hwa University
Taiwan, Checheng
National Museum of Marine Biology and Aquarium Taiwan
Chang, Wenbeen
Taiwan, Checheng
National Museum of Marine Biology and Aquarium Taiwan
Taiwan, Shoufeng
National Dong Hwa University
Chen, Huei Mei
Taiwan, Pingtung
Lee's Endocrinology Clinic
El-Shazly, Mohamed
Taiwan, Kaohsiung
Kaohsiung Medical University
Egypt, Cairo
Faculty of Pharmacy - Ain Shams University
Du, Yingchi
Taiwan, Kaohsiung
Kaohsiung Medical University
Kung, Ting Hsuan
Taiwan, Shoufeng
National Dong Hwa University
Chen, Yucheng
Taiwan, Shoufeng
National Dong Hwa University
Sung, Ping Jyun Sung
Taiwan, Shoufeng
National Dong Hwa University
Taiwan, Checheng
National Museum of Marine Biology and Aquarium Taiwan
Ho, Yuan Shing
Taiwan, Taipei
Council of Agriculture
Kuo, Fu Wen
Taiwan, Checheng
National Museum of Marine Biology and Aquarium Taiwan
Lu, Mei Chin
Taiwan, Shoufeng
National Dong Hwa University
Taiwan, Checheng
National Museum of Marine Biology and Aquarium Taiwan
Statistics
Citations: 11
Authors: 11
Affiliations: 6
Identifiers
Doi:
10.3390/molecules171011839
e-ISSN:
14203049
Research Areas
Cancer
Genetics And Genomics