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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Influence of nonpolio enteroviruses and the bacterial gut microbiota on oral poliovirus vaccine response: A study from south India
Journal of Infectious Diseases, Volume 219, No. 8, Year 2019
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Description
Background. Oral poliovirus vaccine (OPV) is less immunogenic in low-or middle-income than in high-income countries. We tested whether bacterial and viral components of the intestinal microbiota are associated with this phenomenon. Methods. We assessed the prevalence of enteropathogens using TaqMan array cards 14 days before and at vaccination in 704 Indian infants (aged 6-11 months) receiving monovalent type 3 OPV (CTRI/2014/05/004588). Nonpolio enterovirus (NPEV) serotypes were identifed by means of VP1 sequencing. In 120 infants, the prevaccination bacterial microbiota was characterized using 16S ribosomal RNA sequencing. Results. We detected 56 NPEV serotypes on the day of vaccination. Concurrent NPEVs were associated with a reduction in OPV seroconversion, consistent across species (odds ratio [95% confdence interval], 0.57 [.36-.90], 0.61 [.43-.86], and 0.69 [.41-1.16] for species A, B, and C, respectively). Recently acquired enterovirus infections, detected at vaccination but not 14 days earlier, had a greater interfering effect on monovalent type 3 OPV seroresponse than did persistent infections, with enterovirus detected at both time points (seroconversion in 44 of 127 infants [35%] vs 63 of 129 [49%]; P =.02). Te abundance of specifc bacterial taxa did not differ signifcantly according to OPV response, although the microbiota was more diverse in nonresponders at the time of vaccination. Conclusion. Enteric viruses have a greater impact on OPV response than the bacterial microbiota, with recent enterovirus infections having a greater inhibitory effect than persistent infections. © 2018 The Author(s).
Available Materials
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https://efashare.b-cdn.net/share/pmc/articles/PMC6601701/bin/jiy568_suppl_supplementary_table_s1.docx
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https://efashare.b-cdn.net/share/pmc/articles/PMC6601701/bin/jiy568_suppl_supplementary_table_s3.docx
https://efashare.b-cdn.net/share/pmc/articles/PMC6601701/bin/jiy568_suppl_supplementary_table_s4.docx
https://efashare.b-cdn.net/share/pmc/articles/PMC6601701/bin/jiy568_suppl_supplementary_table_s5.docx
https://efashare.b-cdn.net/share/pmc/articles/PMC6601701/bin/jiy568_suppl_supplementary_table_s6.docx
https://efashare.b-cdn.net/share/pmc/articles/PMC6601701/bin/jiy568_suppl_supplementary_table_s7.docx
https://efashare.b-cdn.net/share/pmc/articles/PMC6601701/bin/jiy568_suppl_supplementary_table_s8.docx
Authors & Co-Authors
Praharaj, Ira
India, Vellore
Christian Medical College, Vellore
Parker, Edward P.K.
India, Vellore
Christian Medical College, Vellore
Giri, Sidhartha
India, Vellore
Christian Medical College, Vellore
Allen, David James
United Kingdom, London
Imperial College London
Silas, Sophia
India, Vellore
Christian Medical College, Vellore
Puthupalayam Kaliappan, Saravanakumar Puthupalayam
India, Vellore
Christian Medical College, Vellore
John, Jacob Kochukaleekal
United Kingdom, London
London School of Hygiene & Tropical Medicine
Kampmann, Beate B.
United Kingdom, London
Public Health England
Iturriza-Gómara, Miren
United Kingdom, Royston
National Institute for Health and Care Research
Grassly, Nicholas C.
India, Vellore
Christian Medical College, Vellore
Kang, Gagandeep
India, Vellore
Christian Medical College, Vellore
Statistics
Citations: 30
Authors: 11
Affiliations: 5
Identifiers
Doi:
10.1093/infdis/jiy568
ISSN:
00221899
Research Areas
Health System And Policy
Study Design
Cross Sectional Study
Case-Control Study