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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
neuroscience
Microglia cells protect neurons by direct engulfment of invading neutrophil granulocytes: A new mechanism of CNS immune privilege
Journal of Neuroscience, Volume 28, No. 23, Year 2008
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Description
Microglial cells maintain the immunological integrity of the healthy brain and can exert protection from traumatic injury. During ischemic tissue damage such as stroke, peripheral immune cells acutely infiltrate the brain and may exacerbate neurodegeneration. Whether and how microglia can protect from this insult is unknown. Polymorphonuclear neutrophils (PMNs) are a prominent immunologic infiltrate of ischemic lesions in vivo. Here, we show in organotypic brain slices that externally applied invading PMNs massively enhance ischemic neurotoxicity. This, however, is counteracted by additional application of microglia. Time-lapse imaging shows that microglia exert protection by rapid engulfment of apoptotic, but, strikingly, also viable, motile PMNs in cell culture and within brain slices. PMN engulfment is mediated by integrin- and lectin-based recognition. Interference with this process using RGDS peptides and N-acteyl-glucosamine blocks engulfment of PMNs and completely abrogates the neuroprotective function of microglia. Thus, engulfment of invading PMNs by microglia may represent an entirely new mechanism of CNS immune privilege. Copyright © 2008 Society for Neuroscience.
Authors & Co-Authors
Neumann, Jens
Germany, Magdeburg
Otto-von-guericke-universität Magdeburg
Germany, Magdeburg
Leibniz Institute for Neurobiology
Sauerzweig, Steven
Germany, Magdeburg
Otto-von-guericke-universität Magdeburg
Rönicke, Raik
Germany, Magdeburg
Otto-von-guericke-universität Magdeburg
Gunzer, Frank
Egypt, New Cairo
German University in Cairo
Dinkel, Klaus
Germany, Magdeburg
Otto-von-guericke-universität Magdeburg
Ullrich, Oliver
Germany, Magdeburg
Otto-von-guericke-universität Magdeburg
Switzerland, Zurich
Universität Zürich, Medizinische Fakultät
Gunzer, Matthias
Germany, Magdeburg
Otto-von-guericke-universität Magdeburg
Germany, Braunschweig
Helmholtz Centre for Infection Research Hzi
Reymann, Klaus G.
Germany, Magdeburg
Otto-von-guericke-universität Magdeburg
Germany, Magdeburg
Institute for Applied Neuroscience (institute Für Angewandte Neurowissenschaften Fan Ggmbh)
Germany, Magdeburg
Leibniz Institute for Neurobiology
Statistics
Citations: 246
Authors: 8
Affiliations: 6
Identifiers
Doi:
10.1523/JNEUROSCI.0060-08.2008
ISSN:
02706474
e-ISSN:
02706474
Research Areas
Noncommunicable Diseases
Violence And Injury