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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Characteristics of healthy vascular ageing in pooled population-based cohort studies: The global metabolic syndrome and artery research consortium
Journal of Hypertension, Volume 36, No. 12, Year 2018
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Description
Objective: Arterial ageing is characterized by increasing arterial stiffness as measured by pulse wave velocity (PWV) This process is enhanced in participants with early vascular ageing (EVA), but slowed in participants with healthy vascular ageing (HVA). We aimed to describe characteristics of EVA and HVA in a transcontinental study including 11 cohorts. Methods: In all, 18490 participants from the global MAR Consortium, free of cardiovascular disease, participated with data on PWV and cardiometabolic risk factors. We defined HVA as the lowest 10% and EVA as the highest 10% of the standardized PWV distribution, adjusted for age intervals. HVA individuals were compared with the 90% of non-HVA individuals with ANCOVA, adjusted for age, sex and hypertension. Results: The 1723 HVA participants were at the same age as the rest of the population, more likely women (59.4 vs 57.0%), and with significantly lower levels of established cardiovascular risk factors (blood pressure, lipids, glucose). Similarly, the prevalence rate of obesity, diabetes mellitus, hypertension and the metabolic syndrome was lower in the HVA participants. In the presence of similar levels of cardiovascular risk factors, HVA participants in the 50-64 years of age group presented lower PWV 5.8 (SD 0.5) vs. 7.4 (1.4) m/s (P<0.0001) than control individuals in the 35-49 years of age group, corresponding to an estimated difference in chronological age of 14 years. Conclusion: Participants with healthy vascular ageing (HVA), belonging to the lowest end of the PWV distribution, are in general characterized by an up to 14 years estimated younger biological (vascular) age than those with higher PWV values, and have lower levels of risk factors. © 2018 Wolters Kluwer Health, Inc. All rights reserved.
Authors & Co-Authors
Nilsson, Peter M.
Sweden, Lund
Skånes Universitetssjukhus
Laurent, Stéphane L.
France, Paris
Parcc - Paris-centre de Recherche Cardiovasculaire
Cunha, P. G.
Portugal, Guimaraes
Hospital da Senhora da Oliveira
Portugal, Braga
Universidade do Minho
Olsen, Michael Hecht
Denmark, Odense
Odense Universitetshospital
Rietzschel, Ernst Robert
Belgium, Ghent
Universiteit Gent
Franco, Oscar H.
Netherlands, Rotterdam
Erasmus Mc
Vlachopoulos, Charalambos V.
Greece, Athens
School of Medicine
Chen, Chenhuan
Taiwan, Taipei
National Yang-ming University Taiwan
Boutouyrie, Pierre H.
France, Paris
Parcc - Paris-centre de Recherche Cardiovasculaire
Cucca, Francesco
Italy, Rome
Consiglio Nazionale Delle Ricerche
Lakatta, Edward G.
United States, Bethesda
National Institutes of Health Nih
Scuteri, Angelo
Italy, Rome
Irccs San Raffaele Pisana
Statistics
Citations: 87
Authors: 12
Affiliations: 14
Identifiers
Doi:
10.1097/HJH.0000000000001824
ISSN:
02636352
Research Areas
Noncommunicable Diseases
Study Design
Cross Sectional Study
Cohort Study
Participants Gender
Female