Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Liver function test abnormalities in Nigerian patients with human immunodeficiency virus and hepatitis B virus co-infection
International Journal of STD and AIDS, Volume 24, No. 6, Year 2013
Notification
URL copied to clipboard!
Description
Data on baseline hepatic function of HIV and hepatitis B virus (HBV) co-infected patients are limited in sub-Saharan Africa. We assessed liver function test (LFT) abnormalities in Nigerian patients with HIV/HBV co-infection to highlight the impact of HIV on HBV-related liver disease in sub-Saharan Africa. A cross-sectional study involving 100 HIV/HBV co-infected patients and 100 age- and sex-matched HBV mono-infected controls. Blood testing for HIV antibodies, CD4+ cell count, hepatitis B surface antigen (HBsAg), hepatitis B e antigen (HBeAg), LFTs, platelet count, fasting blood glucose and lipid profile were carried out. Non-invasive hepatic fibrosis scores (aspartate aminotransferase-platelet ratio index [APRI] and FIB-4) were also calculated. Co-infected patients had deranged liver enzymes more than the controls (77% versus 64%, P = 0.04). The predominant patterns of enzyme derangement in co-infected patients were either predominantly ↑ALP (30% versus 4%, P < 0.0001) or mixed (30% versus 15%, P = 0.01) but predominantly ↑AST/ALT in the controls (25% versus 9%, P = 0.003). Co-infected patients had higher fibrosis scores for both APRI (P = 0.002) and FIB-4 (P = 0.0001). On further analysis, LFT abnormalities and fibrosis scores were only significantly higher in co-infected patients in the immune clearance and HBeAg-negative chronic hepatitis phases. LFT abnormalities are common in Nigerians with HBV infection and co-infection with HIV negatively impacts on hepatic function. © The Author(s) 2013 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav.
Authors & Co-Authors
Iroezindu, Michael Onyebuchi
Nigeria, Naukka
University of Nigeria
Agbaji, Oche Ochai O.
Nigeria, Jos
University of Jos
Daniyam, Comfort A.
Nigeria, Jos
University of Jos
Isiguzo, Godsent
Nigeria, Jos
University of Jos
Isichei, Christian Ogoegbulam
Nigeria, Jos
University of Jos
Akanbi, Maxwell O.
Nigeria, Jos
University of Jos
Statistics
Citations: 16
Authors: 6
Affiliations: 2
Identifiers
Doi:
10.1177/0956462412473889
ISSN:
09564624
Research Areas
Infectious Diseases
Study Design
Cross Sectional Study
Study Approach
Quantitative