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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Paucity of CD4
+
CCR5
+
T cells is a typical feature of natural SIV hosts
Blood, Volume 109, No. 3, Year 2007
Notification
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Description
In contrast to lentiviral infections of humans and macaques, simian immunodeficiency virus (SIV) infection of natural hosts is nonpathogenic despite high levels of viral replication. However, the mechanisms underlying this absence of disease are unknown. Here we report that natural hosts for SIV infection express remarkably low levels of CCR5 on CD4+ T cells isolated from blood, lymph nodes, and mucosal tissues. Given that this immunologic feature is found in 5 different species of natural SIV hosts (sooty mangabeys, African green monkeys, mandrills, sun-tailed monkeys, and chimpanzees) but is absent in 5 nonnatural/recent hosts (humans, rhesus, pigtail, cynomolgus macaques, and baboons), it may represent a key feature of the coevolution between the virus and its natural hosts that led to a nonpathogenic infection. Beneficial effects of low CCR5 expression on CD4 + T cells may include the reduction of target cells for viral replication and a decreased homing of activated CD4+ T cells to inflamed tissue. © 2007 by The American Society of Hematology.
Authors & Co-Authors
Pandrea, Ivona Vasile
United States, Covington
Tulane National Primate Research Center
Apétrei, C.
United States, Covington
Tulane National Primate Research Center
Gordon, Shari N.
United States, Philadelphia
University of Pennsylvania
United States, Atlanta
Emory University
Barbercheck, Joseph
United States, Covington
Tulane National Primate Research Center
Dufour, Jason
United States, Covington
Tulane National Primate Research Center
Bohm, Rudolf
United States, Covington
Tulane National Primate Research Center
Sumpter, Beth
United States, Atlanta
Emory University
Roques, Pierre A.
Gabon, Franceville
Centre International de Recherches Medicales de Franceville
Marx, Preston A.
United States, Covington
Tulane National Primate Research Center
Hirsch, Vanessa M.
United States, Bethesda
National Institute of Allergy and Infectious Diseases Niaid
Kaur, Amitinder
United States, Southborough
New England Regional Primate Research Center
Lackner, Andrew A.
United States, Covington
Tulane National Primate Research Center
Veazey, Ronald S.
United States, Covington
Tulane National Primate Research Center
Silvestri, Guido Do
United States, Philadelphia
University of Pennsylvania
United States, Atlanta
Emory University
Statistics
Citations: 14
Authors: 14
Affiliations: 6
Identifiers
Doi:
10.1182/blood-2006-05-024364
ISSN:
00064971
e-ISSN:
00064971