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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
Effect of pH on the conformation and biological activity of Clostridium septicum alpha-toxin, a pore-forming hemolysin
American Journal of Animal and Veterinary Sciences, Volume 2, No. 2, Year 2007
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Description
The effects of pH on the pore-forming Clostridium septicum alpha-toxin that causes myonecrosis was assessed at pH 5.0, 7.0 and 9.0 by measuring circular dichroism and its biological activity. Incubation of the toxin at pH 5.0 increased the hemolytic activity measured in murine red blood cells. On the other hand, incubation of the toxin at pH 9.0 drastically reduces the biological activity of the toxin by five-fold. This study presents the first evidence of the effect of pH on the functional properties of alpha-toxin directly related to the common disease caused by C. septicum in animals and humans i.e. traumatic and non traumatic gas gangrene. © 2007 Science Publications.
Authors & Co-Authors
Hang'Ombe, Bernard Mudenda
Zambia, Lusaka
University of Zambia
Kohda, Tomoko
Japan, Osaka
Osaka Metropolitan University
Mukamoto, Masafumi
Japan, Osaka
Osaka Metropolitan University
Kozaki, Shunji
Japan, Osaka
Osaka Metropolitan University
Statistics
Citations: 4
Authors: 4
Affiliations: 2
Identifiers
Doi:
10.3844/ajavsp.2007.46.49
ISSN:
15574555
e-ISSN:
15574563