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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Evaluation of the performance of four rapid tests for detection of hepatitis B surface antigen in Antananarivo, Madagascar
Journal of Virological Methods, Volume 151, No. 2, Year 2008
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Description
Four rapid immunochromatographic assays - Determine™ HBsAg, Virucheck® HBsAg, Cypress HBsAg Dipstick® and Hexagon® HBsAg - for human hepatitis B surface antigen (HBsAg) detection in human serum were evaluated. A collection of reference serum samples (91 HBsAg positive and 109 HBsAg negative) stored at -80 °C was used. Sensitivity and positive predictive value (PPV) exceeded 95%, and specificity and negative predictive value (NPV) exceeded 96% for all tests. The Determine™ HBsAg test performed best in this study, with a sensitivity of 97.8%, a specificity and PPV of 100%, a NPV of 98.2% and an accuracy rate of 99.0%. However, the differences between the tests were not significant. Other factors should therefore also be taken into account by the Ministry of Health in its decision to recommend a particular test: price, availability, delivery time and feasibility of whole-blood testing. The Determine test appears to be the most suitable for Madagascar, based on all these criteria. The use of this test, despite its lower sensitivity, could prevent blood-borne transmission of hepatitis B virus (HBV) in areas with limited resources. © 2008 Elsevier B.V. All rights reserved.
Authors & Co-Authors
Randrianirina, Frédérique
Madagascar, Antananarivo
Institut Pasteur de Madagascar
Carod, Jean François
Madagascar, Antananarivo
Institut Pasteur de Madagascar
Ratsima, Elisoa Hariniaina
Madagascar, Antananarivo
Institut Pasteur de Madagascar
Chrétien, Jean Baptiste
Madagascar, Antananarivo
Institut Pasteur de Madagascar
Richard, Vincent
Madagascar, Antananarivo
Institut Pasteur de Madagascar
Talarmin, Antoine
Madagascar, Antananarivo
Institut Pasteur de Madagascar
Statistics
Citations: 53
Authors: 6
Affiliations: 1
Identifiers
Doi:
10.1016/j.jviromet.2008.03.019
ISSN:
01660934
Research Areas
Infectious Diseases
Study Locations
Madagascar