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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
Evidence for frequent reinfection with human immunodeficiency virus type 1 of a different subtype
Journal of Virology, Volume 79, No. 16, Year 2005
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Description
A major premise underlying current human immunodeficiency virus type 1 (HIV-1) vaccine approaches is that preexisting HIV-1-specific immunity will block or reduce infection. However, the recent identification of several cases of HIV-1 reinfection suggests that the specific immune response generated for chronic HIV-1 infection may not be adequate to protect against infection by a second HIV-1 strain. It has been unclear, though, whether these individuals are representative of the global epidemic or are rare cases. Here we show that in a population of high-risk women, HIV-1 reinfection occurs almost as commonly as first infections. The study was designed to detect cases of reinfection by HIV-1 of a different subtype and thus captured cases where there was considerable diversity between the first and second strain. In each case, the second virus emerged ∼1 year after the first infection, and in two cases, it emerged when viral levels were high, suggesting that a well-established HIV-1 infection may provide little benefit in terms of immunizing against reinfection, at least by more-divergent HFV-1 variants. Our findings indicate an urgent need for studies of larger cohorts to determine the incidence and timing of both intersubtype and intrasubtype reinfection. Copyright © 005, American Society for Microbiology. All Rights Reserved.
Authors & Co-Authors
Chohan, Bhavna H.
United States, Seattle
Fred Hutchinson Cancer Research Center
United States, Seattle
University of Washington
Kenya, Mombasa
Coast Provincial General Hospital, Kenya
Lavreys, Ludo
United States, Seattle
University of Washington
Kenya, Nairobi
University of Nairobi
Rainwater, Stephanie M.J.
United States, Seattle
Fred Hutchinson Cancer Research Center
Overbaugh, Julie M.
United States, Seattle
Fred Hutchinson Cancer Research Center
Statistics
Citations: 119
Authors: 4
Affiliations: 4
Identifiers
Doi:
10.1128/JVI.79.16.10701-10708.2005
ISSN:
0022538X
Research Areas
Infectious Diseases
Study Design
Cross Sectional Study
Cohort Study
Participants Gender
Female