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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Association of a CD24 gene polymorphism with susceptibility to systemic lupus erythematosus
Arthritis and Rheumatism, Volume 56, No. 9, Year 2007
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Description
Objective. To determine the potential role of the CD24 A57V gene polymorphism in systemic lupus erythematosus (SLE). Methods. We studied 3 cohorts of Caucasian patients and controls. The Spanish cohort included 696 SLE patients and 539 controls, the German cohort included 257 SLE patients and 317 controls, and the Swedish cohort included 310 SLE patients and 247 controls. The CD24 A57V polymorphism was genotyped by polymerase chain reaction, using a predeveloped TaqMan allele discrimination assay. Odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated. Results. In the Spanish cohort there was a statistically significant difference in the distribution of the CD24 V allele between SLE patients and controls (OR 3.6 [95% CI 2.13-6.16], P < 0.0001). In addition, frequency of the CD24 V/V genotype was increased in SLE patients compared with controls (OR 3.7 [95% CI 2.16-6.34], P < 0.00001). We sought to replicate this association with SLE in a German population and a Swedish population. A similar trend was found in the German group. The CD24 V/V genotype and the CD24 V allele were more frequent in SLE patients than in controls, although this difference was not statistically significant. No differences were observed in the Swedish group. A meta-analysis of the Spanish and German cohorts demonstrated that the CD24 V allele has a risk effect in SLE patients (pooled OR 1.25 [95% CI 1.08-1.46], P = 0.003). In addition, homozygosity for the CD24 V risk allele significantly increased the effect (pooled OR 2.19 [95% CI 1.50-3.22], P = 0.00007). Conclusion. These findings suggest that the CD24 A57V polymorphism plays a role in susceptibility to SLE in a Spanish population. © 2007, American College of Rheumatology.
Authors & Co-Authors
Sabio, José Marío
Spain, Granada
Complejo Hospitalario Universitario de Granada
González-Gay, Miguel Ángel
Spain, Lugo
Complejo Hospitalario Xeral Calde
Ortego-Centeno, Norberto
Spain, Granada
Hospital Universitario San Cecilio
de Rámon, Enrique
Spain, Malaga
Hospital Regional Universitario Carlos Haya
Sánchez-Román, Julio
Spain, Sevilla
Hospital Universitario Virgen Del Rocío
Lõpez-Nevot, Miguel Ángel
Spain, Granada
Complejo Hospitalario Universitario de Granada
Gunnarsson, Iva
Sweden, Stockholm
Karolinska Institutet
Svenungsson, Elisabet
Sweden, Stockholm
Karolinska Institutet
Truedsson, Lennart
Sweden, Lund
Skånes Universitetssjukhus
Gónzalez-Escribano, María Francisca
Spain, Sevilla
Hospital Universitario Virgen Del Rocío
Witte, Torsten
Germany, Hannover
Hannover Medical School
Alarcón-Riquelme, Marta Eugenia
Sweden, Uppsala
Uppsala Universitet
Martin, Javier
Spain, Madrid
Consejo Superior de Investigaciones Científicas
Peter, Hanshartmut
Germany, Freiburg Im Breisgau
Universitätsklinikum Freiburg
Zeidler, Henning K.
Germany, Hannover
Hannover Medical School
Schmidt, Reinhold Ernst
Germany, Hannover
Hannover Medical School
Statistics
Citations: 50
Authors: 16
Affiliations: 12
Identifiers
Doi:
10.1002/art.22871
ISSN:
00043591
Research Areas
Genetics And Genomics
Study Design
Cross Sectional Study
Cohort Study
Study Approach
Systematic review