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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Nevirapine concentrations in saliva measured by thin layer chromatography and self-reported adherence in patients on antiretroviral therapy at kilimanjaro christian medical centre, Tanzania
Therapeutic Drug Monitoring, Volume 36, No. 3, Year 2014
Notification
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Description
BACKGROUND: Thin layer chromatography (TLC) can be used to perform therapeutic drug monitoring in resource-limited settings, where more expensive analytical methods, such as high-performance liquid chromatography or liquid chromatography-mass spectrometry, are not feasible. OBJECTIVES: The aim of this cross-sectional study was to compare saliva concentrations of nevirapine (NVP) with self-reported adherence in patients on NVP-containing antiretroviral treatment at Kilimanjaro Christian Medical Centre, Moshi, Tanzania. METHODS: HIV-infected patients using a combination of zidovudine + lamivudine + NVP, or stavudine + lamivudine + NVP, for more than 4 weeks were included. Saliva samples were collected using dental cotton rolls impregnated with citric acid (20 mg). Saliva NVP concentrations were analyzed using TLC. Adherence to ARV medication was assessed by self-reporting using the Morisky scale. RESULTS: Of the 91 study participants, 79 (86.8%) had therapeutic saliva NVP concentrations (ie, >1.75 mg/L) and 12 (13.2%) had subtherapeutic concentrations. Self-reported adherence among the study participants was high in 62 participants (68.1%), moderate in 24 (26.4%), and low in 5 (5.5%). Fifty-seven (91.9%) of the study participants with high self-reported adherence had therapeutic saliva NVP concentrations. Of the 5 participants with low self-reported adherence, 3 had therapeutic NVP concentrations. CONCLUSIONS: A high proportion of patients had therapeutic NVP saliva concentrations as measured by TLC, which showed a good agreement with self-reported adherence. © 2014 by Lippincott Williams & Wilkins.
Authors & Co-Authors
George, Lutengano
Tanzania, Moshi
Kilimanjaro Christian Medical University College
Muro, Eva Prosper
Tanzania, Moshi
Kilimanjaro Christian Medical University College
Tanzania, Moshi
Kilimanjaro Clinical Research Institute
Ndaro, Arnold J.
Tanzania, Moshi
Kilimanjaro Christian Medical University College
Dolmans, Wil M.V.W.M.V.
United States
Nijmegen Institute for Infection
Burger, David Marinus
United States
Nijmegen Institute for Infection
Netherlands, Nijmegen
Radboud University Medical Center
Kisanga, Elton Richard
Tanzania, Moshi
Kilimanjaro Christian Medical University College
Tanzania, Moshi
Kilimanjaro Clinical Research Institute
Statistics
Citations: 12
Authors: 6
Affiliations: 4
Identifiers
Doi:
10.1097/FTD.0000000000000005
ISSN:
01634356
e-ISSN:
15363694
Research Areas
Health System And Policy
Infectious Diseases
Study Design
Cross Sectional Study
Study Approach
Quantitative
Study Locations
Tanzania