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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Immunisation against East Coast fever by the infection and treatment method: Evaluation of the use of ice baths for field delivery and appraisal of an acid formulation of long-acting tetracycline
Veterinary Parasitology, Volume 99, No. 3, Year 2001
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Description
Immunisation by the infection and treatment method using the Katete strain is currently the most efficient prophylactic technique to control East Coast fever (ECF) in the endemic areas of the Eastern Province of Zambia. The maintenance of the cold chain in liquid nitrogen up to the time of inoculation and the cost of the reference long-acting oxytetracycline (Terramycin LA®, Pfizer) are the main drawbacks of the method. The work presented in this paper aims at reducing the cost of immunisation against ECF by using an ice bath for the field delivery and a cheaper long-acting oxytetracycline formulation as chemotherapeutic agent. In experimental conditions, the results from 40 calves immunised after various periods of storage on ice ranging from 4 to 32 h indicate that deferred immunisation performed with a stabilate kept on ice for up to 6 h after thawing has an efficiency of 90%. Moreover, sporozoites kept on ice were still surviving 32 h after thawing. In a field trial, 91 calves were inoculated with a stabilate kept for 3.5-5.5 h after thawing and dilution whereas 86 calves were immunised using the standard method. Clinical and parasitological reactions to immunisation were monitored as well as the seroconversion. In the field trial, the deferred immunisation was more efficient than the standard method. The acid formulation of oxytetracycline that was tested was found as suitable as the reference alkaline formulation for the chemotherapeutic control of the Katete strain in ECF immunisation. One indoor trial was carried out on 10 animals and a field trial involved 93 calves. © 2001 Elsevier Science B.V. All rights reserved.
Authors & Co-Authors
Marcotty, Tanguy
Belgium, Antwerpen
Prins Leopold Instituut Voor Tropische Geneeskunde
Billiouw, Michel
Belgium, Antwerpen
Prins Leopold Instituut Voor Tropische Geneeskunde
Chaka, George
Zambia, Kasama
Provincial Veterinary Office
Berkvens, Dirk L.
Belgium, Antwerpen
Prins Leopold Instituut Voor Tropische Geneeskunde
Losson, Bertrand
Belgium, Liege
Université de Liège
Brandt, Jozef R.A.
Belgium, Antwerpen
Prins Leopold Instituut Voor Tropische Geneeskunde
Statistics
Citations: 25
Authors: 6
Affiliations: 3
Identifiers
Doi:
10.1016/S0304-4017(01)00462-9
ISSN:
03044017
Study Locations
Zambia