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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
A study of the role of immunological factors in the pathogenesis of the anaemia of acute malaria
Transactions of the Royal Society of Tropical Medicine and Hygiene, Volume 72, No. 4, Year 1978
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Description
Children with acute Plasmodium falciparum malaria and anaemia were investigated to see if immunological factors could be implicated in the pathogenesis of their anaemia. Direct Coombs tests using an anti-whole immunoglobulin antiserum were negative in all 12 children tested but two had positive tests with antisera to C3b and C3d. Low plasma levels of C3 and C4 were found but these were not significandy different from values found in a group of children with acute malaria who were not anaemic. Serum levels of immune complexes were normal at the time of their presentation at hospital with anaemia but were elevated one month later. Incubation of group O rhesus-negative red cells in a serum pool obtained from children with acute malaria and anaemia did not cause enhanced haemolysis or reduce their survival time on injection into mice. Splenic uptake of red cells was, however, significantly enhanced. We conclude that the anaemia of acute malaria is due mainly to destruction of red cells by malaria parasites and to enhanced erythrophagocytosis of normal cells. © 1978 Oxford university press.
Authors & Co-Authors
Greenwood, Brian M.
Nigeria, Zaria
Ahmadu Bello University
Stratton, D.
Nigeria, Zaria
Ahmadu Bello University
Williamson, W. A.
Nigeria, Zaria
Ahmadu Bello University
Mohammed, Idris
United Kingdom, London
Barts and the London School of Medicine and Dentistry
Mohammed, I.
Nigeria, Bauchi
University Bauchi
Statistics
Citations: 25
Authors: 5
Affiliations: 3
Identifiers
Doi:
10.1016/0035-9203(78)90131-1
ISSN:
00359203
e-ISSN:
18783503
Research Areas
Health System And Policy
Infectious Diseases
Maternal And Child Health