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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
general
A deep learning system accurately classifies primary and metastatic cancers using passenger mutation patterns
Nature Communications, Volume 11, No. 1, Article 728, Year 2020
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Description
In cancer, the primary tumour’s organ of origin and histopathology are the strongest determinants of its clinical behaviour, but in 3% of cases a patient presents with a metastatic tumour and no obvious primary. Here,as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, we train a deep learning classifier to predict cancer type based on patterns of somatic passenger mutations detected in whole genome sequencing (WGS) of 2606 tumours representing 24 common cancer types produced by the PCAWG Consortium. Our classifier achieves an accuracy of 91% on held-out tumor samples and 88% and 83% respectively on independent primary and metastatic samples, roughly double the accuracy of trained pathologists when presented with a metastatic tumour without knowledge of the primary. Surprisingly, adding information on driver mutations reduced accuracy. Our results have clinical applicability, underscore how patterns of somatic passenger mutations encode the state of the cell of origin, and can inform future strategies to detect the source of circulating tumour DNA. © 2020, The Author(s).
Authors & Co-Authors
Polak, Paz P.
United States, Cambridge
Massachusetts Institute of Technology
United States, Boston
Harvard Medical School
United States, Boston
Massachusetts General Hospital
United States, New York
Icahn School of Medicine at Mount Sinai
Cuppen, Edwin P.J.G.
Netherlands, Utrecht
University Medical Center Utrecht
Boutros, Paul C.
Canada, Toronto
Ontario Institute for Cancer Research
Canada, Toronto
University of Toronto
United States, Los Angeles
University of California, Los Angeles
Campbell, Peter J.
United Kingdom, Hinxton
Wellcome Sanger Institute
United Kingdom, Cambridge
University of Cambridge
Deshpande, Vikram S.
United States, Boston
Massachusetts General Hospital
Faltas, Bishoy Morris
United States, New York
Weill Cornell Medicine
Faquin, William C.
United States, Boston
Massachusetts General Hospital
Garraway, Levi A.
United States, Boston
Dana-farber Cancer Institute
Getz, Gad A.
United States, Cambridge
Massachusetts Institute of Technology
United States, Boston
Harvard Medical School
United States, Boston
Massachusetts General Hospital
Grimmond, Sean M.
Australia, Melbourne
University of Melbourne
Hoadley, Katherine A.
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Lazar, A. J.
United States, Houston
The University of Texas Md Anderson Cancer Center
Louis, David N.
United States, Boston
Massachusetts General Hospital
Omberg, Larsson
United States, Seattle
Sage Bionetworks
Semple, Colin A.M.
United Kingdom, Edinburgh
The University of Edinburgh
Shibata, Tatsuhiro
Japan, Chuo-ku
National Cancer Center Research Institute
Japan, Tokyo
The University of Tokyo
Siebert, Reiner
Germany, Kiel
Christian-albrechts-universität zu Kiel
Germany, Ulm
Universität Ulm
Stobbe, Miranda D.
Spain, Barcelona
Barcelona Institute of Science and Technology Bist
Spain, Barcelona
Universitat Pompeu Fabra Barcelona
De Ridder, Jeroen
Netherlands, Utrecht
University Medical Center Utrecht
van Herpen, Carla Marie Louise
Netherlands, Nijmegen
Radboud University Medical Center
Aaltonen, Lauri A.
Finland, Helsinki
Helsingin Yliopisto
Abascal, Federico
United Kingdom, Hinxton
Wellcome Sanger Institute
Adams, David J.
United Kingdom, Hinxton
Wellcome Sanger Institute
Alawi, Malik
Germany, Hamburg
Universitätsklinikum Hamburg-eppendorf
Germany, Hamburg
Heinrich-pette-institut Leibniz-institut Für Experimentelle Virologie
Alexandrov, Ludmil B.
United Kingdom, Hinxton
Wellcome Sanger Institute
United States, La Jolla
University of California, San Diego
United States, La Jolla
Moores Cancer Center
Alsop, Kathryn
Australia, Melbourne
Peter Maccallum Cancer Centre
Amary, Fernanda M.
United Kingdom, Stanmore
Royal National Orthopaedic Hospital Nhs Trust
Ammerpohl, Ole
Germany, Kiel
Christian-albrechts-universität zu Kiel
Germany, Ulm
Universität Ulm
Armenia, Joshua
United States, New York
Memorial Sloan-kettering Cancer Center
Asa, Sylvia L.
Canada, Toronto
University Health Network University of Toronto
United Kingdom, Nottingham
Nottingham University Hospitals Nhs Trust
Aukema, Sietse M.
Germany, Ulm
Universität Ulm
Germany, Kiel
Christian-albrechts-universität zu Kiel
Awadalla, Philip
Canada, Toronto
Ontario Institute for Cancer Research
Canada, Toronto
University of Toronto
Baez-Ortega, Adrian
United Kingdom, Cambridge
University of Cambridge
Bandopadhayay, Pratiti
United States, Cambridge
Massachusetts Institute of Technology
United States, Boston
Dana-farber Cancer Institute
United States, Boston
Harvard Medical School
Barnholtz-Sloan, Jill S.
United States, Cleveland
Case School of Medicine
United States, Cleveland
University Hospitals Case Medical Center
Barr, Hugh M.D.
United Kingdom, Gloucester
Gloucestershire Royal Hospital
Bathe, Oliver F.
Canada, Calgary
University of Calgary
Bavi, Prashant P.
Canada, Toronto
Ontario Institute for Cancer Research
Behren, Andreas
Australia, Melbourne
La Trobe University
Beltrán, Sergi
Spain, Barcelona
Barcelona Institute of Science and Technology Bist
Spain, Barcelona
Universitat Pompeu Fabra Barcelona
Berchuck, Andrew
United States, Durham
Duke University Medical Center
Bergmann, Anke K.
Germany, Hannover
Hannover Medical School
Bergstrom, Erik N.
United States, La Jolla
University of California, San Diego
United States, La Jolla
Moores Cancer Center
Berney, Daniel Maurice
United Kingdom, London
Queen Mary University of London
Bernhart, Stephan H.F.
Germany, Leipzig
Universität Leipzig
Bieg, Matthias
Germany, Berlin
Charité – Universitätsmedizin Berlin
Germany, Heidelberg
German Cancer Research Center
Binder, Hans
Germany, Leipzig
Universität Leipzig
Birney, Ewan
United Kingdom, Hinxton
European Molecular Biology Laboratory
Birrer, Michael J.
United States, Boston
Massachusetts General Hospital
Biswas, Nidhan K.
India, Kalyani
National Institute of Biomedical Genomics
De Bono, Johann Sebastian
United Kingdom, London
The Institute of Cancer Research
Borg, Åke
Sweden, Lund
Lunds Universitet
Borkhardt, Arndt K.
Germany, Dusseldorf
Heinrich-heine-universität Düsseldorf
Boroevich, Keith Anthony
Japan, Yokohama
Riken Center for Integrative Medical Sciences
Boultwood, Jacqueline
United Kingdom, Oxford
University of Oxford
Bourque, Guillaume
Canada, Montreal
Université Mcgill
Bowen, David T.
United Kingdom, Hinxton
Wellcome Sanger Institute
United Kingdom, Leeds
Leeds Teaching Hospitals Nhs Trust
Bowlby, Reanne
Canada, Vancouver
Canada‘s Michael Smith Genome Sciences Centre
Bowtell, David D.L.
Australia, Melbourne
Peter Maccallum Cancer Centre
Brazma, A. N.
United Kingdom, Hinxton
European Molecular Biology Laboratory
Brennan, Paul J.
Switzerland, Geneva
Organisation Mondiale de la Santé
Brock, Jane E.
United States, Boston
Brigham and Women's Hospital
Broeks, Annegien
Netherlands, Amsterdam
The Netherlands Cancer Institute
Brooks, Denise B.
Canada, Vancouver
Canada‘s Michael Smith Genome Sciences Centre
Brors, Benedikt
Germany, Heidelberg
German Cancer Research Center
Buchhalter, Ivo
Germany, Heidelberg
German Cancer Research Center
Germany, Heidelberg
Universität Heidelberg
Bullman, Susan
United States, Cambridge
Massachusetts Institute of Technology
United States, Boston
Dana-farber Cancer Institute
Burkhardt, Birgit
Germany, Munster
Universitätsklinikum Münster
Butler, Adam P.
United Kingdom, Hinxton
Wellcome Sanger Institute
Borresen-Dale, Anne Lise
Norway, Oslo
Rikshospitalet-radiumhospitalet hf
Norway, Oslo
Universitetet I Oslo
Caesar-Johnson, Samantha J.
United States, Bethesda
National Institutes of Health Nih
Calvo, Fabien
France, Villejuif
Institut de Cancerologie Gustave Roussy
Campo, Elías
Spain, Barcelona
Institut D'investigacions Biomèdiques August pi I Sunyer - Idibaps
Cazzola, Mario
Italy, Pavia
Università Degli Studi Di Pavia
Cebon, Jonathan Simon
Australia, Melbourne
La Trobe University
Cerfolio, Robert James
United States, Birmingham
The University of Alabama at Birmingham
Chalmers, Don R.C.
Australia, Hobart
University of Tasmania
Chan-Seng-Yue, Michelle A.
Canada, Toronto
Ontario Institute for Cancer Research
Chanock, Stephen J.
United States, Bethesda
National Institutes of Health Nih
Chantrill, Lorraine A.
Australia, Sydney
The Kinghorn Cancer Centre
Chayama, Kazuaki
Japan, Higashihiroshima
Hiroshima University
Chiew, Yoke Eng
Australia, Parramatta
The Westmead Institute for Medical Research
Australia, Sydney
Westmead Hospital
Chin, Suet Feung
United Kingdom, Cambridge
University of Cambridge
Cho, Juok
United States, Cambridge
Massachusetts Institute of Technology
Chomienne, Christine
France, Boulogne-billancourt
Institut National du Cancer
Chou, Angela S.Y.
Australia, Sydney
The Kinghorn Cancer Centre
Australia, Parramatta
The Westmead Institute for Medical Research
Cibulskis, Kristian
United States, Cambridge
Massachusetts Institute of Technology
Clapham, Peter
United Kingdom, Hinxton
Wellcome Sanger Institute
Claviez, Alexander
Germany, Kiel
Universitätsklinikum Schleswig-holstein Campus Kiel
Cloonan, Nicole
New Zealand, Auckland
The University of Auckland
Collins, Colin C.
Canada, Vancouver
Vancouver Prostate Centre
Cooke, Susanna L.
United Kingdom, Glasgow
University of Glasgow
Cordner, Stephen M.
Australia, Melbourne
Victorian Institute of Forensic Medicine
Cortes-Ciriano, Isidro
United States, Boston
Harvard Medical School
United Kingdom, Cambridge
University of Cambridge
Creighton, Chad J.
United States, Houston
Baylor College of Medicine
de la Vega, Francisco M.
United States, Stanford
Stanford University School of Medicine
United States, Palo Alto
Stanford University
DeFreitas, Timothy
United States, Cambridge
Massachusetts Institute of Technology
Delaneau, Olivier
Switzerland, Lausanne
Université de Lausanne Unil
Switzerland, Geneva
Université de Genève Faculté de Médecine
Switzerland, Lausanne
Sib Swiss Institute of Bioinformatics
Demchok, John A.
United States, Bethesda
National Institutes of Health Nih
Desmedt, Christine
Belgium, Brussels
Institut Jules Bordet
Belgium, Leuven
Ku Leuven
Dhir, Rajiv J.
United States, Pittsburgh
Upmc Shadyside
Dinh, Huy Q.
United States, Los Angeles
Cedars-sinai Medical Center
Dirix, Luc Yves
Belgium, Antwerpen
Universiteit Antwerpen
Doddapaneni, Harshavardhan
United States, Houston
Baylor College of Medicine
Drechsel, O.
Spain, Barcelona
Universitat Pompeu Fabra Barcelona
Spain, Barcelona
Barcelona Institute of Science and Technology Bist
Dudderidge, Tim J.
United Kingdom, Southampton
University Hospital Southampton Nhs Foundation Trust
United Kingdom, London
The Royal Marsden Nhs Foundation Trust
Dursi, Lewis Jonathan
Canada, Toronto
Ontario Institute for Cancer Research
Canada, Toronto
Hospital for Sick Children University of Toronto
Duthie, Fraser R.
United Kingdom, Glasgow
University of Glasgow
United Kingdom, Glasgow
Queen Elizabeth University Hospital, Glasgow
Dutton-Regester, Ken
Australia, Brisbane
Qimr Berghofer Medical Research Institute
Easton, Douglas F.
United Kingdom, Cambridge
University of Cambridge
Eeles, Rosalind A.
United Kingdom, London
The Institute of Cancer Research
United Kingdom, London
The Royal Marsden Nhs Foundation Trust
Escaramis, Georgia
Spain, Barcelona
Barcelona Institute of Science and Technology Bist
Spain, Madrid
Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública
Estivill, Xavier
Spain, Barcelona
Barcelona Institute of Science and Technology Bist
Etemadmoghadam, Dariush
Australia, Melbourne
Peter Maccallum Cancer Centre
Eyfjörd, Jórunn Erla
Iceland, Reykjavik
Icelandic Cancer Society
Fassan, Matteo
Italy, Padua
Università Degli Studi Di Padova
Felau, Ina
United States, Bethesda
National Institutes of Health Nih
Fereday, Sian
Australia, Melbourne
Peter Maccallum Cancer Centre
Ferguson, Martin L.
United States, Bethesda
National Institutes of Health Nih
Ferretti, Vincent
Canada, Toronto
Ontario Institute for Cancer Research
Canada, Montreal
University of Montreal
Fisher, Cyril J.
United Kingdom, London
The Royal Marsden Nhs Foundation Trust
Fitzgerald, Rebecca Claire
United Kingdom, Cambridge
University of Cambridge
Flanagan, Adrienne Margaret
United Kingdom, London
University College London
Fleshner, Neil Eric
Canada, Toronto
Princess Margaret Cancer Centre
Flicek, Paul R.
United Kingdom, Hinxton
European Molecular Biology Laboratory
Fong, Kwun M.
Australia, Chermside
The Prince Charles Hospital
Fonseca, Nuno A.
United Kingdom, Hinxton
European Molecular Biology Laboratory
Portugal, Porto
Universidade do Porto
Frazer, Scott
United States, Cambridge
Massachusetts Institute of Technology
Frenkel-Morgenstern, Milana
Israel, Ramat Gan
Bar-ilan University
Fronick, Catrina C.
United States, St. Louis
Washington University in St. Louis
United Kingdom, Norwich
Norfolk and Norwich University Hospitals Nhs Foundation Trust
Fulton, Robert S.
United States, St. Louis
Washington University in St. Louis
United States, St. Louis
Washington University School of Medicine in St. Louis
Gabriel, Stacey Bolk
United States, Cambridge
Massachusetts Institute of Technology
Gallinger, Steven J.
Canada, Toronto
Ontario Institute for Cancer Research
Canada, Toronto
University Health Network University of Toronto
Canada, Toronto
Mount Sinai Hospital of University of Toronto
Gambacorti Passerini, Carlo B.
Italy, Milan
Università Degli Studi Di Milano-bicocca
Garrison, Erik P.
United Kingdom, Hinxton
Wellcome Sanger Institute
Gehlenborg, Nils
United States, Cambridge
Massachusetts Institute of Technology
United States, Boston
Harvard Medical School
Gelpí, Josep Lluís
Spain, Barcelona
Centro Nacional de Supercomputación
Spain, Barcelona
Universitat de Barcelona
Gerhard, Daniela Se
United States, Bethesda
National Institutes of Health Nih
Gerhäuser, Clarissa
Germany, Heidelberg
German Cancer Research Center
Ghori, Mohammed J.R.
United Kingdom, Hinxton
Wellcome Sanger Institute
Gibbs, Richard A.
United States, Houston
Baylor College of Medicine
Gill, Anthony J.
Australia, Sydney
The Kinghorn Cancer Centre
Australia, Sydney
The University of Sydney
Gill, Pelvender Singh
United Kingdom, Oxford
University of Oxford
Giri, Dilip D.
United States, New York
Memorial Sloan-kettering Cancer Center
Gnanapragasam, Vincent J.
United Kingdom, Cambridge
Cambridge University Hospitals Nhs Foundation Trust
United Kingdom, Cambridge
University of Cambridge
Gossage, James A.
United Kingdom, London
St Thomas' Hospital
Graham, Janet Shirley
United Kingdom, Glasgow
University of Glasgow
United Kingdom, Glasgow
Beatson West of Scotland Cancer Centre
Green, Anthony Reidunn T.
United Kingdom, Cambridge
University of Cambridge
Green, Eric D.
United States, Bethesda
National Institutes of Health Nih
Grossman, Robert Lee
United States, Chicago
The University of Chicago
Grundhoff, Adam T.
Germany, Hamburg
Heinrich-pette-institut Leibniz-institut Für Experimentelle Virologie
Germany, Hamburg
Partner Site Hamburg-lübeck-borstel-riems
Gut, I. Glynne
Spain, Barcelona
Barcelona Institute of Science and Technology Bist
Spain, Barcelona
Universitat Pompeu Fabra Barcelona
Gut, Marta
Spain, Barcelona
Barcelona Institute of Science and Technology Bist
Spain, Barcelona
Universitat Pompeu Fabra Barcelona
Haider, Syed Asma
Canada, Toronto
Ontario Institute for Cancer Research
Hamdy, Freddie C.
United Kingdom, Oxford
University of Oxford
Hamilton, Anne L.
Australia, Melbourne
Peter Maccallum Cancer Centre
Hanna, George Bushra
United Kingdom, London
Imperial College London
Hansmann, Martin Leo
Germany, Frankfurt am Main
Senckenberg Forschungsinstitut Und Naturmuseum
Harmanci, Arif Ozgun
United States, New Haven
Yale University
United States, Houston
University of Texas Health Science Center at Houston
Harrington, Eoghan Donal
United Kingdom, Oxford
Oxford Nanopore Technologies
Heath, Simon C.
Spain, Barcelona
Barcelona Institute of Science and Technology Bist
Spain, Barcelona
Universitat Pompeu Fabra Barcelona
Hedley, David William
Canada, Toronto
Princess Margaret Cancer Centre
Hegde, Apurva M.
United States, Houston
The University of Texas Md Anderson Cancer Center
Heinold, Michael C.
Germany, Heidelberg
German Cancer Research Center
Germany, Heidelberg
Universität Heidelberg
Heisler, Lawrence E.
Canada, Toronto
Ontario Institute for Cancer Research
Helmy, Mohamed
Canada, Toronto
University of Toronto
Hobolth, Asger
Denmark, Aarhus
Aarhus Universitet
Hoell, Jessica I.
Germany, Dusseldorf
Heinrich-heine-universität Düsseldorf
Hoffmann, Steve
Germany, Leipzig
Universität Leipzig
Germany, Jena
Leibniz Institute on Aging - Fritz Lipmann Institute
Hofmann, Oliver M.
Australia, Melbourne
University of Melbourne
Hou, Yong
China, Shenzhen
Bgi-shenzhen
China, Shenzhen
China National Genebank
Hovestadt, Volker
Germany, Heidelberg
German Cancer Research Center
Hua, Xing
United States, Bethesda
National Institutes of Health Nih
Huang, Mei
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Huber, Wolfgang K.
Germany, Heidelberg
European Molecular Biology Laboratory Heidelberg
Hudson, Thomas J.
Canada, Toronto
Ontario Institute for Cancer Research
United States, North Chicago
Abbvie
Hummel, Michael
Germany, Berlin
Charité – Universitätsmedizin Berlin
Hung, Jillian A.
Australia, Parramatta
The Westmead Institute for Medical Research
Australia, Sydney
Westmead Hospital
Huntsman, David G.
Canada, Vancouver
British Columbia Cancer Agency
Hupp, Ted R.
United Kingdom, Edinburgh
Royal Infirmary of Edinburgh
Hutter, Barbara
Germany, Heidelberg
German Cancer Research Center
Hutter, Carolyn M.
United States, Bethesda
National Institutes of Health Nih
Hübschmann, Daniel
Germany, Heidelberg
Universität Heidelberg
Germany, Heidelberg
Universitätsklinikum Heidelberg
Germany, Heidelberg
German Cancer Research Center
Imoto, Seiya
Japan, Tokyo
The University of Tokyo
Isaacs, William B.
United States, Baltimore
Johns Hopkins Medicine
Ishikawa, Shumpei
Japan, Tokyo
The University of Tokyo
Iskar, Murat
Germany, Heidelberg
German Cancer Research Center
Ittmann, Michael M.
United States, Houston
Baylor College of Medicine
United States, Houston
Michael E. Debakey va Medical Center
Jacquemier, Jocelyne D.
South Korea, Seoul
Hanyang University
Jayaseelan, Joy Christina
United States, Houston
Baylor College of Medicine
Ji, Yuan
United States, Chicago
The University of Chicago
United States, Evanston
Northshore University Healthsystem
Johns, Amber L.
Australia, Sydney
The Kinghorn Cancer Centre
Joly, Yann
Canada, Montreal
Université Mcgill
Jonasson, J. G.
Iceland, Reykjavik
Icelandic Cancer Society
Jones, Corbin D.
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Jones, David R.
United Kingdom, Hinxton
Wellcome Sanger Institute
Jones, David T.W.
Germany, Heidelberg
Hopp Children's Cancer Center Heidelberg Kitz
Germany, Heidelberg
German Cancer Research Center
Kahles, André
United States, New York
Memorial Sloan-kettering Cancer Center
Switzerland, Zurich
Eth Zürich
Switzerland, Lausanne
Sib Swiss Institute of Bioinformatics
Switzerland, Zurich
Universitatsspital Zurich
Von-Kalle, Christof
Germany, Heidelberg
German Cancer Research Center
Karlan, Beth Y.
United States, Los Angeles
Cedars-sinai Medical Center
Kassahn, Karin S.
Australia, Brisbane
The University of Queensland
Kebebew, Electron K.
United States, Washington, D.c.
The George Washington University
United States, Bethesda
National Institutes of Health Nih
Kellis, Manolis
United States, Cambridge
Massachusetts Institute of Technology
Kench, J. G.
Australia, Sydney
The Kinghorn Cancer Centre
Australia, Sydney
The University of Sydney
Australia, Sydney
Royal Prince Alfred Hospital
Kennedy, Catherine J.
Australia, Parramatta
The Westmead Institute for Medical Research
Australia, Sydney
Westmead Hospital
Khoo, Vincent S.
United Kingdom, London
The Royal Marsden Nhs Foundation Trust
Kilpinen, Helena
United Kingdom, London
University College London
Kim, Jaegil
United States, Cambridge
Massachusetts Institute of Technology
King, Tari A.
United States, Boston
Dana-farber Cancer Institute
United States, New York
Memorial Sloan-kettering Cancer Center
United States, Boston
Brigham and Women's Hospital
Klapper, Wolfram
Germany, Kiel
Christian-albrechts-universität zu Kiel
Kleinheinz, Kortine
Germany, Heidelberg
German Cancer Research Center
Germany, Heidelberg
Universität Heidelberg
Knappskog, Stian
United Kingdom, Hinxton
Wellcome Sanger Institute
Norway, Bergen
Universitetet I Bergen
Knoppers, Bartha Maria
Canada, Montreal
Université Mcgill
Kool, Marcel
Germany, Heidelberg
Hopp Children's Cancer Center Heidelberg Kitz
Germany, Heidelberg
German Cancer Research Center
Korbel, Jan O.
United Kingdom, Hinxton
European Molecular Biology Laboratory
Germany, Heidelberg
European Molecular Biology Laboratory Heidelberg
Korchina, Viktoriya
United States, Houston
Baylor College of Medicine
Korshunov, Andrey G.
Germany, Heidelberg
German Cancer Research Center
Kóte-Jarai, Zsofia S.
United Kingdom, London
The Institute of Cancer Research
Kremeyer, Barbara
United Kingdom, Hinxton
Wellcome Sanger Institute
Lagergren, Jesper H.F.
Sweden, Stockholm
Karolinska Institutet
United Kingdom, London
King's College London
Laird, Peter W.
United States, Grand Rapids
Van Andel Research Institute
Lakhani, Sunil R.
Australia, Brisbane
Royal Brisbane and Women's Hospital
Lamaze, Fabien C.
Canada, Toronto
Ontario Institute for Cancer Research
Lander, Eric S.
United States, Cambridge
Massachusetts Institute of Technology
Larsimont, Denis P.
Belgium, Brussels
Institut Jules Bordet
Lathrop, Mark G.
Canada, Montreal
Université Mcgill
Lawerenz, Chris
Germany, Berlin
Charité – Universitätsmedizin Berlin
Lawlor, Rita T.
Unknown Affiliation
Lee, Ming Ta Michael
Taiwan, Nankang
Academia Sinica Taiwan
Lehmann, Kjong Van
United States, New York
Memorial Sloan-kettering Cancer Center
Switzerland, Zurich
Eth Zürich
Switzerland, Lausanne
Sib Swiss Institute of Bioinformatics
Switzerland, Zurich
Universitatsspital Zurich
Lehrach, Hans R.
Germany, Berlin
Max Planck Institute for Molecular Genetics
Lenze, Dido
Germany, Berlin
Charité – Universitätsmedizin Berlin
Leshchiner, Ignaty D.
United States, Cambridge
Massachusetts Institute of Technology
Letunić, Ivica
Unknown Affiliation
Lewis, Lora R.
United States, Houston
Baylor College of Medicine
Li, Haiyan Irene
Canada, Vancouver
Canada‘s Michael Smith Genome Sciences Centre
Lin, Pei
United States, Cambridge
Massachusetts Institute of Technology
Liu, Dongbing
China, Shenzhen
Bgi-shenzhen
China, Shenzhen
China National Genebank
Liu, Jia
United States, Reston
Leidos Inc.
Livingstone, Julie M.
Canada, Toronto
Ontario Institute for Cancer Research
Loeffler, Markus
Germany, Leipzig
Universität Leipzig
Long, Georgina V.
Unknown Affiliation
Lovat, Laurence Bruce
United Kingdom, London
University College London
Lu, Yongjie
United Kingdom, London
Queen Mary University of London
China, Shanghai
Second Military Medical University
Luchini, Claudio
Unknown Affiliation
Lynch, Andy G.
United Kingdom, Cambridge
University of Cambridge
United Kingdom, St Andrews
School of Medicine
López, Cristina E.
Germany, Kiel
Christian-albrechts-universität zu Kiel
Germany, Ulm
Universität Ulm
Ma, Yussanne P.
Canada, Vancouver
Canada‘s Michael Smith Genome Sciences Centre
Macintyre, Geoff
United Kingdom, Cambridge
University of Cambridge
Maitra, Arindam
India, Kalyani
National Institute of Biomedical Genomics
Majumder, Partha Pratim
India, Kalyani
National Institute of Biomedical Genomics
Malcovati, Luca
Italy, Pavia
Università Degli Studi Di Pavia
Malleo, Giuseppe
Unknown Affiliation
Marchal, Kathleen
Belgium, Ghent
Universiteit Gent
Mardis, Elaine R.
United States, St. Louis
Washington University in St. Louis
United States, Philadelphia
Fox Chase Cancer Center
United States, Columbus
Nationwide Children’s Hospital
Marques-Bonet, Tomas
Spain, Barcelona
Barcelona Institute of Science and Technology Bist
Spain, Barcelona
Csic-upf - Instituto de Biologia Evolutiva Ibe
Spain, Barcelona
Institució Catalana de Recerca I Estudis Avançats
Spain, Cerdanyola Del Valles
Institut Català de Paleontologia Miquel Crusafont
Martens, J. W. M. W.M.
Netherlands, Rotterdam
Erasmus Mc
Martín-Subero, J. I.
Spain, Barcelona
Institució Catalana de Recerca I Estudis Avançats
Spain, Barcelona
Institut D'investigacions Biomèdiques August pi I Sunyer - Idibaps
Martincorena, Iñigo
United Kingdom, Hinxton
Wellcome Sanger Institute
Matthews, Lucy H.
United Kingdom, London
The Institute of Cancer Research
Meier, Samuel R.
United States, Cambridge
Massachusetts Institute of Technology
Menzies, Andrew
United Kingdom, Hinxton
Wellcome Sanger Institute
Merrett, Neil D.
Australia, Penrith
Western Sydney University
Meyerson, Matthew L.
United States, Cambridge
Massachusetts Institute of Technology
United States, Boston
Dana-farber Cancer Institute
United States, Boston
Harvard Medical School
Meyerson, William U.
United States, New Haven
Yale University
Mileshkin, Linda Rose
Australia, Melbourne
Peter Maccallum Cancer Centre
Minner, Sarah J.P.
Germany, Hamburg
Universitätsklinikum Hamburg-eppendorf
Mirabello, Lisa J.
United States, Bethesda
National Institutes of Health Nih
Miyano, Satoru
Japan, Tokyo
The University of Tokyo
Moore, Richard A.
Canada, Vancouver
Canada‘s Michael Smith Genome Sciences Centre
Morrison, Carl D.
Australia, Melbourne
University of Melbourne
United States, Buffalo
Roswell Park Cancer Institute
Mungall, Karen L.
Canada, Vancouver
Canada‘s Michael Smith Genome Sciences Centre
Mustonen, Ville
Finland, Helsinki
Helsingin Yliopisto
Muzny, Donna Marie
United States, Houston
Baylor College of Medicine
Möller, Peter Lange
Germany, Ulm
Universität Ulm
Nakagawa, Hidewaki
Japan, Yokohama
Riken Center for Integrative Medical Sciences
Navarro, Arcadi
Spain, Barcelona
Barcelona Institute of Science and Technology Bist
Spain, Barcelona
Csic-upf - Instituto de Biologia Evolutiva Ibe
Spain, Barcelona
Institució Catalana de Recerca I Estudis Avançats
Neal, David E.
United Kingdom, Cambridge
University of Cambridge
United Kingdom, Cambridge
Cambridge University Hospitals Nhs Foundation Trust
Newton, Yulia
United States, Santa Cruz
University of California, Santa Cruz
Noble, Michael S.
United States, Cambridge
Massachusetts Institute of Technology
Northcott, Paul A.
United States, Memphis
St. Jude Children's Research Hospital
O'Donovan, Maria L.
United Kingdom, Cambridge
University of Cambridge
Ogden, Christopher W.
United Kingdom, London
The Royal Marsden Nhs Foundation Trust
Ohdan, Hideki
Japan, Higashihiroshima
Hiroshima University
Ojesina, Akinyemi I.
United States, Birmingham
The University of Alabama at Birmingham
United States, Huntsville
Hudsonalpha Institute for Biotechnology
Ossowski, Stephan
Spain, Barcelona
Universitat Pompeu Fabra Barcelona
Spain, Barcelona
Barcelona Institute of Science and Technology Bist
Germany, Tubingen
Eberhard Karls Universität Tübingen
Ott, German K.
Germany, Stuttgart
Robert Bosch Krankenhaus Stuttgart
Ouellette, Bf Francis
Canada, Toronto
Ontario Institute for Cancer Research
Canada, Toronto
University of Toronto
Paiella, Salvatore
Unknown Affiliation
Pan-Hammarström, Qiang
China, Shenzhen
Bgi-shenzhen
Sweden, Stockholm
Karolinska Institutet
Papatheodorou, Irene
United Kingdom, Hinxton
European Molecular Biology Laboratory
Parker, Joel S.
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Patch, Ann Marie
Australia, Brisbane
The University of Queensland
Australia, Brisbane
Qimr Berghofer Medical Research Institute
Pennell, Nathan A.
United States, Cleveland
Cleveland Clinic Foundation
Olson, Gloria Moy
United States, Rochester
Mayo Clinic
Pfister, Stefan Michael
Germany, Heidelberg
Hopp Children's Cancer Center Heidelberg Kitz
Germany, Heidelberg
German Cancer Research Center
Germany, Heidelberg
Universitätsklinikum Heidelberg
Pihl, Todd D.
United States, Reston
General Dynamics Corporation
Pillay, Nischalan
United Kingdom, London
University College London
Pinder, Sarah E.
United Kingdom, London
Imperial College Academic Health Science Centre
Pivot, Xavier B.
France, Besancon
Interactions Hôte-greffon, Tumeur et Ingénierie Cellulaire et Génique
Popescu, Irinel
Romania, Bucharest
Institutul Clinic Fundeni
Preston, Shaun R.
United Kingdom, Guildford
Royal Surrey County Hospital
Pritchard, Antonia L.
Australia, Brisbane
Qimr Berghofer Medical Research Institute
Provenzano, Elena
United Kingdom, Cambridge
Cambridge University Hospitals Nhs Foundation Trust
Pulido-Tamayo, Sergio
Belgium, Ghent
Universiteit Gent
Purdie, Colin A.
United Kingdom, Dundee
Ninewells Hospital
Rader, Janet S.
United States, Milwaukee
Medical College of Wisconsin
Raeder, Benjamin
Germany, Heidelberg
European Molecular Biology Laboratory Heidelberg
Ramalingam, Suresh S.
United States, Atlanta
Emory University
Reifenberger, Guido
Germany, Dusseldorf
Heinrich-heine-universität Düsseldorf
Reis-Filho, Jorge Sérgio
United States, New York
Memorial Sloan-kettering Cancer Center
Reynolds, Sheila M.
United States, Seattle
Institute for Systems Biology
Riazalhosseini, Yasser
Canada, Montreal
Université Mcgill
Roach, Jeffrey M.
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Roberts, Lewis Rowland
United States, Rochester
Mayo Clinic
Roques, Tom W.
United Kingdom, Norwich
Norfolk and Norwich University Hospitals Nhs Foundation Trust
Rosenstiel, Philip C.
Germany, Kiel
Christian-albrechts-universität zu Kiel
Rosenwald, Andreas R.
Germany, Wurzburg
Julius-maximilians-universität Würzburg
Rowe, Edward W.J.
United Kingdom, London
The Royal Marsden Nhs Foundation Trust
United Kingdom, Bristol
North Bristol Nhs Trust
Rozen, Steven George
Singapore, Singapore City
Duke-nus Medical School
Singapore, Singapore City
National University of Singapore
Rubin, Mark A.
Switzerland, Bern
University of Bern
United States, New York
Weill Cornell Medicine
Ruzzenente, Andrea
Unknown Affiliation
Rätsch, Gunnar
United States, New York
Memorial Sloan-kettering Cancer Center
Switzerland, Zurich
Eth Zürich
Switzerland, Lausanne
Sib Swiss Institute of Bioinformatics
United States, New York
Weill Cornell Medicine
Switzerland, Zurich
Universitatsspital Zurich
Saksena, Gordon
United States, Cambridge
Massachusetts Institute of Technology
Salgado, Roberto A.
Unknown Affiliation
Salvia, Roberto
Unknown Affiliation
Sánchez-Vega, Francisco
United Kingdom, Salford
Salford Royal Nhs Foundation Trust
United States, New York
Memorial Sloan-kettering Cancer Center
Sauter, Guido
Germany, Hamburg
Universitätsklinikum Hamburg-eppendorf
Scarpa, Aldo
Unknown Affiliation
Scélo, Ghislaine A.
Switzerland, Geneva
Organisation Mondiale de la Santé
Schadendorf, Dirk
Germany, Heidelberg
German Cancer Research Center
Germany, Essen
Universitätsklinikum Essen
Schilhabel, Markus B.
Germany, Kiel
Christian-albrechts-universität zu Kiel
Schlesner, Matthias
Germany, Heidelberg
German Cancer Research Center
Schlomm, Thorsten
Germany, Berlin
Charité – Universitätsmedizin Berlin
Germany, Hamburg
Universitätsklinikum Hamburg-eppendorf
Schreiber, Stefan W.
Germany, Kiel
Christian-albrechts-universität zu Kiel
Statistics
Citations: 103
Authors: 335
Affiliations: 324
Identifiers
Doi:
10.1038/s41467-019-13825-8
ISSN:
20411723
Research Areas
Cancer
Genetics And Genomics
Health System And Policy