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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Gastric adenocarcinoma has a unique microRNA signature not present in esophageal adenocarcinoma
Cancer, Volume 119, No. 11, Year 2013
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Description
BACKGROUND MicroRNAs (miRNAs) play critical roles in tumor development and progression. The finding that a single miRNA can regulate hundreds of genes places miRNAs at critical hubs of signaling pathways. For the current study, the authors investigated the miRNA expression profile of gastric adenocarcinomas and compared it with esophageal adenocarcinomas to better identify a unique miRNA signature of gastric adenocarcinoma. METHODS miRNA expression profiles were obtained using 2 different proprietary microarray platforms on primary gastric adenocarcinoma tissue samples. The cross comparison of results identified 17 up-regulated miRNAs and 12 down-regulated miRNAs that overlapped in both platforms. Quantitative real-time polymerase chain reaction was performed for independent validation of a representative set of 8 miRNAs in gastric and esophageal adenocarcinomas compared with normal gastric mucosa or esophageal mucosa, respectively. RESULTS The deregulation of miR-146b-5p, miR-375, miR-148a, miR-31, and miR-451 was associated significantly with gastric adenocarcinomas. Conversely, deregulation of miR-21 (up-regulation) and miR-133b (down-regulation) was detectable in both gastric and esophageal adenocarcinomas. It was noteworthy that miR-200a was significantly down-regulated in gastric adenocarcinoma samples (P =.04) but was up-regulated in esophageal adenocarcinoma samples (P =.001). In addition, the expression level of miR-146b-5p displayed a strong correlation with the tumor stage of gastric cancer. CONCLUSIONS Gastric adenocarcinoma displayed a unique miRNA signature that distinguished it from esophageal adenocarcinoma. This specific signature may reflect differences in the etiology and/or molecular signaling in these 2 closely related cancers. The current findings suggest important miRNA candidates that can be investigated for their biological functions and for their possible diagnostic, prognostic, and therapeutic role in gastric adenocarcinoma. © 2013 American Cancer Society.
Authors & Co-Authors
Chen, Zheng
United States, Nashville
Vanderbilt University Medical Center
China, Nanjing
Nanjing Medical University
Saad, Rama
United States, Nashville
Vanderbilt University Medical Center
Egypt, New Cairo
School of Sciences and Engineering
Jia, Peilin
United States, Nashville
Vanderbilt University Medical Center
Peng, Dunfa
United States, Nashville
Vanderbilt University Medical Center
Zhu, Shoumin
United States, Nashville
Vanderbilt University Medical Center
Washington, Mary Kay
United States, Nashville
Vanderbilt University Medical Center
Zhao, Zhongming Ming
United States, Nashville
Vanderbilt University Medical Center
Xu, Zekuan
China, Nanjing
Nanjing Medical University
El-Rifai, Wa’el M.
United States, Nashville
Vanderbilt University Medical Center
United States, Washington, D.c.
U.s. Department of Veterans Affairs
Statistics
Citations: 9
Authors: 9
Affiliations: 4
Identifiers
Doi:
10.1002/cncr.28002
ISSN:
0008543X
e-ISSN:
10970142
Research Areas
Cancer
Study Approach
Quantitative