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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Evidence for a multiclonal origin of multicentric advanced lesions of kaposi sarcoma
Journal of the National Cancer Institute, Volume 99, No. 14, Year 2007
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Description
Background: Kaposi sarcoma (KS) is a complex tumor of uncertain clonality. Studying the viral clonality of the human herpesvirus 8 (HHV-8) in KS to determine clonality of the tumors, a strategy that has been used previously with Epstein-Barr virus and its associated tumors, may elucidate whether multicentric (disseminated) KS lesions correspond to metastatic lesions or to expansions of independent clones. Methods: Aseries of 139 KS biopsies (from skin, lymph node, or tonsil) was obtained from 98 patients, with 59 biopsies from 18 patients with disseminated multicentric KS skin lesions. The degree of spindle cell infiltration in biopsies was established by direct observation of hematoxylin-eosin-tained sections, and HHV-8 viral load was quantified by real-time polymerase chain reaction. To determine cellular clonality, the size heterogeneity of the HHV-8-fused terminal repeat (TR) region was determined by probing of electrophoresed restricted genomic DNA from KS biopsies for the HHV-8 TR sequence. Results: HHV-8 clonality analysis was performed on the 62 samples for which sufficient DNA was obtained. Most samples corresponded to histologically nodular lesions with high spindle cell infiltration and high viral load. A clonal HHV-8 pattern was determined for 59 samples; 11 were found to be monoclonal and 48 to be oligoclonal. The informative samples that were from disseminated KS skin lesions (n = 26, from six patients) were either monoclonal or oligoclonal, and the size of HHV-8 episomes varied between these samples. Conclusion: Although some tumor KS lesions were monoclonal expansions of HHV-8-infected spindle cells, most advanced lesions were oligoclonal proliferations. Furthermore, individual KS disseminated tumor skin lesions were found to represent distinct expansions of HHV-8-infected spindle cells. Thus, our results suggest that KS lesions, especially in patients with advanced skin tumors, are reactive proliferations rather than true malignancies with metastatic dissemination. © Published by Oxford University Press 2007.
Authors & Co-Authors
Duprez, Renan
France, Paris
Institut Pasteur, Paris
Lacoste, Vincent
France, Paris
Institut Pasteur, Paris
Brier̀e, Josette F.
France, Paris
Hôpital Saint-louis
Couppié, Pierre
French Guiana, Cayenne
Hôpital de Cayenne
Françès, Carnille
France, Paris
Hôpital Universitaire Pitié Salpêtrière
Sainte-Marie, Dominique
French Guiana, Cayenne
Hôpital de Cayenne
Kassa-Kelembho, Eric
Central African Republic, Bangui
Institut Pasteur de Bangui
Lando, Marie Jeanne
Cameroon, Yaounde
Centre Hospitalier et Universitaire de Yaounde
Oyono, Jean Louis Essamé
Cameroon, Yaounde
Centre Pasteur du Cameroun
Nkegoum, Blaise
Cameroon, Yaounde
Centre Hospitalier et Universitaire de Yaounde
Hbid, Oumkaltoum
Morocco, Casablanca
Institut Pasteur du Maroc
Mahé, Antoine
Senegal, Dakar
Institut Dhygiène Sociale Dakar
Lebbé, Céleste
France, Paris
Hôpital Saint-louis
Tortevoye, Patricia
France, Paris
Institut Pasteur, Paris
Huerre, Michel René
France, Paris
Institut Pasteur, Paris
Gessain, Antoine
France, Paris
Institut Pasteur, Paris
Statistics
Citations: 96
Authors: 16
Affiliations: 9
Identifiers
Doi:
10.1093/jnci/djm045
ISSN:
00278874
e-ISSN:
14602105
Research Areas
Cancer
Genetics And Genomics