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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Inhibitory effect of 2-arylbenzofurans from Erythrina addisoniae on protein tyrosine phosphatase-1B
Bioorganic and Medicinal Chemistry Letters, Volume 17, No. 14, Year 2007
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Description
Bioassay-guided fractionation of an EtOAc-soluble extract of the stem bark of Erythrina addisoniae (Leguminosae), using an in vitro PTP1B inhibitory assay, resulted in the isolation of three new (1-3) and three known (4-6) 2-arylbenzofuran derivatives. The new compounds were identified as 2-[2′,4′-dihydroxy-3′-(3-methylbut-2-enyl)phenyl]-6-hydroxybenzofuran (1), 2-[2′-methoxy-4′-hydroxy-5′-(3-methylbut-2-enyl)phenyl]-6-hydroxybenzofuran (2), and 2-(2′-methoxy-4′-hydroxyphenyl)-5-(3-methylbut-2-enyl)-6-hydroxybenzofuran (3). The new 2-arylbenzofurans 1-3 inhibited PTP1B activity with IC50 values ranging from 13.6 ± 1.1 to 17.5 ± 1.2 μM in vitro assay. On the basis of the data obtained, 2-arylbenzofurans with prenyl group may be considered as a new class of PTP1B inhibitors. © 2007 Elsevier Ltd. All rights reserved.
Authors & Co-Authors
Na, Minkyun
South Korea, Daejeon
Korea Research Institute of Bioscience and Biotechnology
Hoang, Duc Manh
South Korea, Daejeon
Korea Research Institute of Bioscience and Biotechnology
Njamen, Dieudonné
Cameroon, Yaounde
Université de Yaoundé I
Mbafor, Joseph Tanyi
Cameroon, Yaounde
Université de Yaoundé I
Fomum, Zacharias Tanee
Cameroon, Yaounde
Université de Yaoundé I
Thuong, Phuong Thien
South Korea, Gwangju
Chosun University
Ahn, Jong Seog
South Korea, Daejeon
Korea Research Institute of Bioscience and Biotechnology
Oh, Won Keun
South Korea, Gwangju
Chosun University
Statistics
Citations: 41
Authors: 8
Affiliations: 3
Identifiers
Doi:
10.1016/j.bmcl.2007.05.005
ISSN:
0960894X