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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
pharmacology, toxicology and pharmaceutics
In vitro antiprotozoal and cytotoxic activity of 33 ethonopharmacologically selected medicinal plants from Democratic Republic of Congo
Journal of Ethnopharmacology, Volume 141, No. 1, Year 2012
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Description
Ethnopharmacological relevance: The antiprotozoal and cytotoxic activity of the aqueous extracts from 33 medicinal plants, used by traditional healers for the treatment of various parasitic diseases and collected after an ethnopharmacological inventory conducted in the Bolongo area, Bandundu province in DR Congo, was evaluated. Materials and methods: Decoctions were prepared, lyophilized and evaluated for in vitro antiprotozoal activity against Trypanosoma b. brucei, Trypanosoma cruzi, Leishmania infantum, and the chloroquine- and pyrimethamine-resistant K1 strain of Plasmodium falciparum. Cytotoxicity against MRC-5 cells was included to assess selectivity of activity. Results: Most of the tested extracts exhibited pronounced (IC 50 ≤ 5 μg/ml) or good (5 < IC 50 ≤ 10 μg/ml) antiprotozoal activity against one or more of the selected protozoa. A total of 19 plant extracts inhibited Trypanosoma b. brucei, especially the extract from Isolona hexaloba stem bark (IC 50 = 1.95 μg/ml, SI = 16.5); 8 plant extracts were active against Trypanosoma cruzi, the extracts from Enanatia chlorantha stem bark and Quassia africana root bark being the most active with IC 50 values of 1.87 and 1.88 μg/ml, respectively (SI = 3.0 and 3.3, respectively); 8 plant extracts showed activity against Leishmania infantum, with extracts from Napoleona vogelii stem bark and Quassia africana root bark as the most active with IC 50 values of 5.66 and 5.04 μg/ml (SI = 11.3 and 1.2). Finally, 9 plant extracts inhibited Plasmodium falciparum K1 with the extracts from Quassia africana (root bark and stem bark) being the most active ones with IC 50 values of 0.46 and 1.27 μg/ml (SI = 13.7 and 13.6). Extracts from Enantia chlorantha stem bark, Piptadeniastrum africanum stem bark and Quassia africana root bark were cytotoxic for MRC-5 cells (CC 50 < 10 μg/ml). Conclusions: These results can partly support and justify the traditional use of some of these plant species for the treatment of parasitic diseases. © 2012 Elsevier Ireland Ltd. All rights reserved.
Authors & Co-Authors
Musuyu Muganza, D.
Democratic Republic Congo, Kinshasa
Universite de Kinshasa
Fruth, Barbara I.
Germany, Leipzig
Max-planck-institut Für Evolutionäre Anthropologie
Nzunzu Lami, J.
Democratic Republic Congo, Kinshasa
Universite de Kinshasa
Mesia, Gauthier Kahunu
Democratic Republic Congo, Kinshasa
Universite de Kinshasa
Kambu, Oscar K.
Democratic Republic Congo, Kinshasa
Universite de Kinshasa
Tona, Gaston L.
Democratic Republic Congo, Kinshasa
Universite de Kinshasa
Cimanga, Kanyanga
Democratic Republic Congo, Kinshasa
Universite de Kinshasa
Belgium, Antwerpen
Universiteit Antwerpen
Cos, Paul G.F.
Belgium, Antwerpen
Universiteit Antwerpen
Maes, Louis J.R.M.
Belgium, Antwerpen
Universiteit Antwerpen
Apers, Sandra
Belgium, Antwerpen
Universiteit Antwerpen
Pieters, Luc A.C.
Belgium, Antwerpen
Universiteit Antwerpen
Statistics
Citations: 108
Authors: 11
Affiliations: 3
Identifiers
Doi:
10.1016/j.jep.2012.02.035
ISSN:
03788741
e-ISSN:
18727573
Study Locations
Congo