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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
HIV-1 diversity and prevalence differ between urban and rural areas in the Mbeya region of Tanzania
AIDS, Volume 19, No. 14, Year 2005
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Description
Objective: To characterize HIV-1 strains in a potential vaccine trial cohort (CODE) in the Mbeya region of southwest Tanzania. Design: Study volunteers (n = 3096) were recruited from urban areas in Mbeya Town, using two different recruitment strategies, and in a nearby rural village. Methods: Cryopreserved plasma from 507 HIV-1 prevalent cases was the source of viral RNA for HIV-1 genotyping by the Multi-region Hybridization Assay, the MHA acd, and selected strains were confirmed by complete genome sequencing. Results: The overall HIV-1 prevalence was 16.6% [95% confidence interval (CI), 15.3-17.9] within the cohort. HIV-1 prevalence was higher among women, and in urban areas. Recruitment through advertisement targeted a high-risk urban male population for HIV-1 infection [adjusted odds ratio (adj. OR), 1.68; 95% CI, 1.13-2.51] when compared with men recruited door-to-door. The complexity of the HIV-1 epidemic was also higher in urban areas evidenced by the high-risk of HIV-1 infection with a recombinant strain (adj. OR, 2.69; 95% CI, 1.08-6.69) and HIV-1 dual infection (adj. OR, 5.16; 95% CI, 1.07-24.9), mainly driven by urban men recruited through advertisement. Conclusions: Overall the urban epidemic was more genetically complex, with higher prevalence and more recombinants and dual infections. Vaccine trials in Mbeya region can assess a complex HIV-1 population dynamic and determine vaccine efficacy in relationship to the genetic diversity of HIV-1 strains that challenge vaccines. © 2005 Lippincott Williams & Wilkins.
Authors & Co-Authors
Arroyo, Miguel A.
Unknown Affiliation
Höelscher, Michael
Unknown Affiliation
Sateren, Warren B.
Unknown Affiliation
Samky, Eleuter
Unknown Affiliation
Maboko, Leonard L.
Unknown Affiliation
Hoffmann, Oliver
Unknown Affiliation
Kijak, Gustavo Hernán
Unknown Affiliation
Robb, Merlin Lee
Unknown Affiliation
Birx, Deborah L.
Unknown Affiliation
McCutchan, Francine E.
Unknown Affiliation
Statistics
Citations: 62
Authors: 10
Affiliations: 7
Identifiers
Doi:
10.1097/01.aids.0000183515.14642.76
Research Areas
Genetics And Genomics
Infectious Diseases
Study Design
Cross Sectional Study
Cohort Study
Case-Control Study
Study Locations
Tanzania
Participants Gender
Male
Female