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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
general
Meningococcal disease in children in Merseyside, england: A 31 year descriptive study
PLoS ONE, Volume 6, No. 10, Article e25957, Year 2011
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Description
Meningococcal disease (MCD) is the leading infectious cause of death in early childhood in the United Kingdom, making it a public health priority. MCD most commonly presents as meningococcal meningitis (MM), septicaemia (MS), or as a combination of the two syndromes (MM/MS). We describe the changing epidemiology and clinical presentation of MCD, and explore associations with socioeconomic status and other risk factors. A hospital-based study of children admitted to a tertiary children's centre, Alder Hey Children's Foundation Trust, with MCD, was undertaken between 1977 to 2007 (n = 1157). Demographics, clinical presentations, microbiological confirmation and measures of deprivation were described. The majority of cases occurred in the 1-4 year age group and there was a dramatic fall in serogroup C cases observed with the introduction of the meningococcal C conjugate (MCC) vaccine. The proportion of MS cases increased over the study period, from 11% in the first quarter to 35% in the final quarter. Presentation with MS (compared to MM) and serogroup C disease (compared to serogroup B) were demonstrated to be independent risk factors for mortality, with odds ratios of 3.5 (95% CI 1.18 to 10.08) and 2.18 (95% CI 1.26 to 3.80) respectively. Cases admitted to Alder Hey were from a relatively more deprived population (mean Townsend score 1.25, 95% CI 1.09 to 1.41) than the Merseyside reference population. Our findings represent one of the largest single-centre studies of MCD. The presentation of MS is confirmed to be a risk factor of mortality from MCD. Our study supports the association between social deprivation and MCD. © 2011 Stanton et al.
Authors & Co-Authors
Stanton, Michelle C.
United Kingdom, Lancaster
Lancaster University
Taylor-Robinson, David Carlton
United Kingdom, Liverpool
University of Liverpool
Makwana, Nick V.
United Kingdom, West Bromwich
Sandwell and West Birmingham Hospitals Nhs Trust
Hackett, Scott J.
United Kingdom, Birmingham
Heartlands Hospital
Baines, Paul B.
United Kingdom, Keele
Keele University
United Kingdom, Liverpool
Alder Hey Children's Nhs Foundation Trust
Riordan, Andrew F.
United Kingdom, Liverpool
Alder Hey Children's Nhs Foundation Trust
Thomson, Alistair P.J.
United Kingdom, Crewe
Leighton Hospital
Diggle, Peter J.
United Kingdom, Lancaster
Lancaster University
Hart, Charles Anthony
United Kingdom, Liverpool
University of Liverpool
Carrol, Enitan D.
United Kingdom, Liverpool
University of Liverpool
United Kingdom, Liverpool
Alder Hey Children's Nhs Foundation Trust
Statistics
Citations: 15
Authors: 10
Affiliations: 7
Identifiers
Doi:
10.1371/journal.pone.0025957
ISSN:
19326203
Research Areas
Health System And Policy
Maternal And Child Health
Study Design
Cross Sectional Study