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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Phytochemical and biological activities of Crataegus sinaica growing in Egypt
Asian Pacific Journal of Tropical Medicine, Volume 3, No. 4, Year 2010
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Description
Objective: To evaluate the cardiac activity and hepatoprotection of Crataegus sinaica (C. sinaica). Methods: All the isolated compounds were isolated by open-column liquid chromatography (CC) using sephadex LH-20 as stationary phase. Elution of the column was performed with EtOH or MeOH. The phytochemical investigation of the young stem of C. sinaica for the first time together with the leaves and flowers lead to the isolation and identification of quercetin, hyperoside, vitexin-2″-O-rhamnoside, epicatechin, procyanidin B2 and procyanidins C1. Results: Rats treated with the low and high dose of C. sinaica leaves with flowers extract showed 15% and 17% reduction in the heart rate, and reduction in the ST-segment by 107% and 57%; respectively. The T-amplitude was decreased by 59% of the high dose extract. On the other hand, the young stems and leaves with flowers extracts of C. sinaica on primary culture of rat hepatocytes monolayer indicated a hepatoprotection for the total extract, ethyl acetate, butanol, and chloroform fractions at 100 μg/mL, 75 μg/mL, 50 μg/mL, and 25μg/mL; respectively. Conclusions: The results of these chemical and biological studies suggest the use of C. sinaica growing in Egypt as a preventive drug against cardiovascular and hepatic diseases. The chemical studies suggest the use of woody young stems as a newly investigated bioactive organ. The extraction of unsaturated fatty acids from the seeds of the plant would serve as a good health and nutritive product. © 2010 Hainan Medical College.
Authors & Co-Authors
Refaat, Alaa Tawfeek
Egypt, Giza
National Research Centre
Shahat, Abdelaaty A.
Egypt, Giza
National Research Centre
Ehsan, Nermine Ahmed
Egypt, Shibin el Kom
Menoufia University
Yassin, Nemat Z.
Egypt, Giza
National Research Centre
Hammouda, Faiza M.
Egypt, Giza
National Research Centre
Tabl, Elsayed Abou
Egypt, Cairo
Faculty of Pharmacy
Ismail, Shams I.
Egypt, Giza
National Research Centre
Statistics
Citations: 23
Authors: 7
Affiliations: 3
Identifiers
Doi:
10.1016/S1995-7645(10)60062-4
ISSN:
19957645
Research Areas
Noncommunicable Diseases
Study Locations
Egypt