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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Metabotropic glutamate receptor subtype-1 is essential for in vivo growth of melanoma
Oncogene, Volume 27, No. 57, Year 2008
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Description
Ectopic expression of metabotropic glutamate receptor subtype 1 (mGluR1) in mouse melanocytes induces melanoma formation. Although requirement of mGluR1 for development of melanoma in the initial stage has been demonstrated, its role in melanoma growth in vivo remains unclear. In this study, we developed novel transgenic mice that conditionally express mGluR1 in melanocytes, using a tetracycline regulatory system. Pigmented lesions on the ears and tails of the transgenic mice began to appear 29 weeks after activation of the mGluR1 transgene, and the transgenic mice produced melanomas at a frequency of 100% 52 weeks after transgene activation. Subsequent inactivation of the mGluR1 transgene in melanoma-bearing mice inhibited melanoma growth with reduction of immunoreactivity to phosphorylated ERK1/2, whereas mice with persistent expression of mGluR1 developed larger melanoma burdens. mGluR1 expression is thus required not only for melanoma development but also for melanoma growth in vivo. These findings suggest that growth of melanoma can be inhibited in vivo by eliminating only one of the multiple genetic anomalies involved in tumorigenesis. © 2008 Macmillan Publishers Limited All rights reserved.
Authors & Co-Authors
Funasaka, Yoko
Japan, Kobe
Graduate School of Medicine
Abdel-Daim, Mohamed M.
Japan, Kobe
Graduate School of Medicine
Sakai, Norio
Japan, Hiroshima
Hiroshima University Graduate School of Biomedical and Health Sciences
Saito, Naoaki
Japan, Kobe
Kobe University
Nishigori, Chikako
Japan, Kobe
Graduate School of Medicine
Statistics
Citations: 62
Authors: 5
Affiliations: 4
Identifiers
Doi:
10.1038/onc.2008.329
ISSN:
14765594
Research Areas
Genetics And Genomics