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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Long-term immunogenicity and efficacy of a 9-valent conjugate pneumococcal vaccine in human immunodeficient virus infected and non-infected children in the absence of a booster dose of vaccine
Vaccine, Volume 25, No. 13, Year 2007
Notification
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Description
The long-term immunogenicity and vaccine efficacy (VE) of a 9-valent conjugate pneumococcal vaccine was studied in HIV infected and HIV non-infected children. VE against vaccine-serotype invasive pneumococcal disease following 6.16 years of follow-up persisted in HIV non-infected children (77.8%; 95% CI 34.4-92.5 compared to 83% after 2.3 years of follow-up), and declined from 65% to 38.8% (95% CI -7.8 to 65.2) in HIV infected children. HIV non-infected vaccinees had equal (serotypes 4, 6B, 14, 19F) or greater (serotypes 9V, 18C, 23F) proportions of serotype-specific antibody concentrations of ≥0.2 μg/ml to vaccine-serotypes analyzed compared to HIV infected vaccinees at 5.3 years of age. © 2006 Elsevier Ltd. All rights reserved.
Authors & Co-Authors
Madhi, Shabir A.
South Africa, Johannesburg
University of the Witwatersrand
Adrian, Peter V.
South Africa, Johannesburg
University of the Witwatersrand
Kuwanda, Locadiah
South Africa, Johannesburg
University of the Witwatersrand
Jassat, Waasila
South Africa, Johannesburg
University of the Witwatersrand
Jones, Stephanie A.
South Africa, Johannesburg
University of the Witwatersrand
Little, Tessa
South Africa, Johannesburg
University of the Witwatersrand
Soininen, Anu
Finland, Helsinki
Terveyden ja Hyvinvoinnin Laitos
Cutland, Clare Louise
South Africa, Johannesburg
University of the Witwatersrand
Klugman, K. P.
South Africa, Johannesburg
University of the Witwatersrand
United States, Atlanta
Rollins School of Public Health
Statistics
Citations: 138
Authors: 9
Affiliations: 3
Identifiers
Doi:
10.1016/j.vaccine.2006.09.019
ISSN:
0264410X
Research Areas
Infectious Diseases
Maternal And Child Health
Study Design
Cohort Study