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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
pharmacology, toxicology and pharmaceutics
Coriander fruit exhibits gut modulatory, blood pressure lowering and diuretic activities
Journal of Ethnopharmacology, Volume 122, No. 1, Year 2009
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Description
Aim of the study: Coriander (Coriandrum sativum) is traditionally used for various gastrointestinal and cardiovascular disorders and this study was designed to rationalize its use in dyspepsia, abdominal colic, diarrhea, hypertension and as diuretic. Materials and methods: Coriander crude extract (Cs.Cr) was evaluated through in vitro and in vivo techniques. Results: Cs.Cr caused atropine sensitive stimulatory effect in isolated guinea-pig ileum (0.1-10 mg/ml). In rabbit jejunum preparations, Cs.Cr evoked a similar contractile response but in the presence of atropine, it exhibited relaxation against both spontaneous and high K+ (80 mM)-induced contractions as well as shifted the Ca2+ concentration-response curves to right, similar to that caused by verapamil. Cs.Cr (1-30 mg/ml) caused fall in arterial blood pressure of anesthetized animals, partially blocked by atropine. Cs.Cr produced vasodilatation against phenylephrine and K+ (80 mM)-induced contractions in rabbit aorta and cardio-depressant effect in guinea-pig atria. Cs.Cr produced diuresis in rats at 1-10 mg/kg. Bio-assay-directed fractionation revealed the separation of spasmogenic and spasmolytic components in the aqueous and organic fractions respectively. Conclusions: These results indicate that coriander fruit exhibits gut stimulatory, inhibitory and hypotensive effects mediating possibly through cholinergic, Ca2+ antagonist and the combination of these mechanisms respectively. Diuretic activity adds value to its use in hypertension. © 2008 Elsevier Ireland Ltd. All rights reserved.
Authors & Co-Authors
Jabeen, Qaiser
Pakistan, Karachi
The Aga Khan University Medical College
Pakistan, Bahawalpur
The Islamia University of Bahawalpur
Bashir, Samra
Pakistan, Karachi
The Aga Khan University Medical College
Lyoussi, Badiâa
Morocco, Fez
Université Sidi Mohamed Ben Abdellah
Gilani, Anwar ul Hassan
Pakistan, Karachi
The Aga Khan University Medical College
Statistics
Citations: 141
Authors: 4
Affiliations: 3
Identifiers
Doi:
10.1016/j.jep.2008.12.016
ISSN:
03788741
Research Areas
Noncommunicable Diseases
Study Locations
Guinea