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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
chemistry
Prenylated xanthone derivatives with antiplasmodial activity from Allanblackia monticola Staner L.C.
Chemical and Pharmaceutical Bulletin, Volume 54, No. 1, Year 2006
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Description
Further study of the methanol extract of the stem bark of Allanblackia monticola Staner L.C. resulted in the isolation of a new prenylated xanthenedione, designated allanxanthone C, together with the five known xanthones, garciniafuran, tovophyllin A, rubraxanthone, norcowanin and mangostin and one saponin, stigmasterol-3-O-β-D-glucopyranoside. The structure of the new compound was established by detailed spectroscopic analysis to be 1,2-dihydro-3,6,8-trihydroxy-1,1,7-tri(3-methylbut-2-enyl)xanthen-2,9-dione (3-hydroxyapetalinone C). The methanol extract and pure compounds were tested on two strains of Plasmodium falciparum, F32 (chloroquine sensitive) and FcM29 (chloroquine resistant). The IC50 values obtained ranged from 0.6 to 8.9 μg/ml. Their cytotoxicity was estimated on human melanoma cells (A375) and the cytotoxicity/antiplasmodial ratio was found to be between 15.45 and 30.46. The antimicrobial activities against a range of microorganisms of the crude extract and some of these compounds are also reported. © 2006 Pharmaceutical Society of Japan.
Authors & Co-Authors
Azébazé, Anatole Guy Blaise
Cameroon, Douala
University of Douala
Meyer, Michèle
France, Paris
Museum National D'histoire Naturelle
Valentin, Alexis
France, Toulouse
Université Toulouse Iii - Paul Sabatier
Nguemfo, Edwige Laure
Cameroon, Yaounde
Université de Yaoundé I
Fomum, Zacharias Tanee
Cameroon, Yaounde
Université de Yaoundé I
Nkengfack, Augustin Ephrem
Cameroon, Yaounde
Université de Yaoundé I
Statistics
Citations: 77
Authors: 6
Affiliations: 4
Identifiers
Doi:
10.1248/cpb.54.111
ISSN:
00092363
e-ISSN:
13475223