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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Absence of Calcitriol-Mediated Nongenomic Actions in Isolated Intestinal Cells of the Damara Mole-Rat (Cryptomys damarensis)
General and Comparative Endocrinology, Volume 95, No. 1, Year 1994
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Description
Calcitriol [1,25(OH)2D3] actions on intestinal calcium transport involve genomic and nongenomic pathways. Whether nongenomic 1,25(OH)2D3-mediated actions are employed was investigated using isolated intestinal epithelial cells of naturally vitamin D-deficient underground-dwelling damara mole-rats (Cryptomys damarensis). 1,25(OH)2D3-mediated nongenomic pathways of intestinal calcium uptake, measured by opening of 1,25(OH)2D3-activated voltage-sensitive Ca2+ channels (VSCC), did not occur. Rapid (1 min) 45Ca2+ transmembrane influx in intestinal cells was not significantly increased by the addition of 1,25(OH)2D3 (at concentrations from 10-12 to 10-6 nM), when compared to opening of VSCC in the presence of a depolarizing (elevated K+) buffer. Furthermore, even after 30 min calcium uptake was not significantly enhanced by the hormone. These findings support earlier reports that duodenal calcium absorption is independent of vitamin D and is a highly adaptive feature of a subterranean existence. © 1994 by Academic Press, Inc.
Authors & Co-Authors
Buffenstein, Rochelle B.
South Africa, Johannesburg
University of the Witwatersrand
Sergeev, I. N.
South Africa, Johannesburg
University of the Witwatersrand
United States, Huntingdon
Marshall University Joan C. Edwards School of Medicine
Pettifor, John M.
South Africa, Johannesburg
University of the Witwatersrand
Statistics
Citations: 4
Authors: 3
Affiliations: 2
Identifiers
Doi:
10.1006/gcen.1994.1098