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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Clinical trial of an F(ab′)
2
polyvalent equine antivenom for African snake bites in Benin
American Journal of Tropical Medicine and Hygiene, Volume 77, No. 3, Year 2007
Notification
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Description
We report the results of a trial designed to measure the safety and efficacy of African Antivipmyn®, a new freeze-dried polyvalent equine F(ab′)2-based antivenom. We tested 289 envenomations. After treatment, 19% of treated patients had undesirable events, all benign. A possible adverse effect was attributed to this antivenom in 11% of the patients. Bleeding was observed in 48% of the patients; it stopped within 2 hours after treatment with antivenom in 60% of the patients. Blood incoagulability was observed in 80% of the patients. Restoration of coagulation was attained within 4 hours in 60% of the patients. Nine patients died; 6 arrived at the hospital in the final stage of complications and 5 arrived at the hospital more than 60 hours after the bite. The value of blood coagulation tests in diagnosis of envenomation and bleeding as an indicator of renewal of treatment are emphasized. Copyright © 2007 by The American Society of Tropical Medicine and Hygiene.
Authors & Co-Authors
Chippaux, Jean Philippe
France, Marseille
Ird Institut de Recherche Pour le Developpement
Massougbodji, Achille
Benin, Cotonou
Laboratoire D'anatomie Humaine de la Faculté Des Sciences de la Santé de Cotonou
Stock, Roberto Pablo
Mexico, Cuernavaca
Instituto de Biotecnología de la Unam
Alagon, A. C.
Mexico, Cuernavaca
Instituto de Biotecnología de la Unam
Fassinou, E.
Unknown Affiliation
Ndamadjo, A.
Unknown Affiliation
Soglo, R.
Unknown Affiliation
Tamou, B. E.
Unknown Affiliation
Mama, A. B.
Unknown Affiliation
Nguemezi, A.
Unknown Affiliation
Salako, Albert Sourou
Unknown Affiliation
Hounyet, J. P.
Unknown Affiliation
Koussémou, A.
Unknown Affiliation
Mongbo, Y. A.
Unknown Affiliation
Santos, A.
Unknown Affiliation
Batonon, Achille
Unknown Affiliation
Loukmann, L.
Unknown Affiliation
Tévoèdjrè, M.
Unknown Affiliation
Yaya, A.
Unknown Affiliation
Agbangla, Y.
Unknown Affiliation
Ahoui, Séraphin
Unknown Affiliation
Agossadou, Chantal
Unknown Affiliation
Statistics
Citations: 67
Authors: 22
Affiliations: 3
Identifiers
Doi:
10.4269/ajtmh.2007.77.538
ISSN:
00029637
Research Areas
Cancer
Health System And Policy
Study Locations
Benin