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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Silent brain infarcts in adult Kuwaiti sickle cell disease patients
American Journal of Hematology, Volume 73, No. 4, Year 2003
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Description
Although overt stroke is a common complication of sickle cell disease (SCD), its incidence is very low in Kuwaiti patients. On the other hand, the prevalence of silent brain infarcts, which is reported to be about 17-20% in American patients, has not been documented in adult Kuwaiti patients. This is a 1-year study of consecutive, asymptomatic SCD patients seen in the hematology clinic of Mubarak Al-Kabeer Hospital. Patients with a past history of seizure or any other neurological abnormality were excluded. The patients' charts were reviewed for frequency of hospitalizations, any documented complications, and steady-state CBC. MRI was done with a 1.5-Tesla unit with super-conducting magnet. T1- and T2-weighted sagittal and axial sections and proton-density axial images were obtained in 5-mm-thick sections. Thirty-five patients were studied, made up of 25 SS and 10 Sβ0Thal, aged between 17 and 44 years, with a mean age of 26.9 ± 9.3 years. MRI findings consistent with infarcts were found in 7 (20.0%) patients - 6 SS and 1 Sβ0thal with a mean age of 31.8 ± 8.2 years, which was significantly higher (P < 0.05) than the mean age of the unaffected group (25.1 - 9.0 years). There were also no differences in the mean Hb, Hb F, or any other hematological parameter in the two groups. Among the affected 6 SS, 2 had co-existent α-thal trait. It is interesting that, while silent infarcts are prevalent in young American patients, it is in the older age group that they occur in Kuwaiti patients. Further studies are needed to investigate the factors modulating this heterogeneity. © 2003 Wiley-Liss, Inc.
Authors & Co-Authors
Marouf, R. A.R.
Kuwait, Kuwait City
Kuwait University
Gupta, Renu K.
Kuwait, Kuwait City
Kuwait University
Haider, Mohammad Zafaryab
Kuwait, Kuwait City
Kuwait University
Adekile, Adekunle D.
Kuwait, Kuwait City
Kuwait University
Statistics
Citations: 44
Authors: 4
Affiliations: 1
Identifiers
Doi:
10.1002/ajh.10376
ISSN:
03618609
Research Areas
Genetics And Genomics
Health System And Policy
Noncommunicable Diseases
Study Design
Cross Sectional Study
Cohort Study