Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Resolved versus confirmed ARDS after 24 h: insights from the LUNG SAFE study
Intensive Care Medicine, Volume 44, No. 5, Year 2018
Notification
URL copied to clipboard!
Description
Purpose: To evaluate patients with resolved versus confirmed ARDS, identify subgroups with substantial mortality risk, and to determine the utility of day 2 ARDS reclassification. Methods: Our primary objective, in this secondary LUNG SAFE analysis, was to compare outcome in patients with resolved versus confirmed ARDS after 24 h. Secondary objectives included identifying factors associated with ARDS persistence and mortality, and the utility of day 2 ARDS reclassification. Results: Of 2377 patients fulfilling the ARDS definition on the first day of ARDS (day 1) and receiving invasive mechanical ventilation, 503 (24%) no longer fulfilled the ARDS definition the next day, 52% of whom initially had moderate or severe ARDS. Higher tidal volume on day 1 of ARDS was associated with confirmed ARDS [OR 1.07 (CI 1.01–1.13), P = 0.035]. Hospital mortality was 38% overall, ranging from 31% in resolved ARDS to 41% in confirmed ARDS, and 57% in confirmed severe ARDS at day 2. In both resolved and confirmed ARDS, age, non-respiratory SOFA score, lower PEEP and P/F ratio, higher peak pressure and respiratory rate were each associated with mortality. In confirmed ARDS, pH and the presence of immunosuppression or neoplasm were also associated with mortality. The increase in area under the receiver operating curve for ARDS reclassification on day 2 was marginal. Conclusions: ARDS, whether resolved or confirmed at day 2, has a high mortality rate. ARDS reclassification at day 2 has limited predictive value for mortality. The substantial mortality risk in severe confirmed ARDS suggests that complex interventions might best be tested in this population. Trial Registration: ClinicalTrials.gov NCT02010073. © 2018, Springer-Verlag GmbH Germany, part of Springer Nature and ESICM.
Authors & Co-Authors
Madotto, Fabiana
Italy, Milan
Università Degli Studi Di Milano-bicocca
Canada, Toronto
Saint Michael's Hospital University of Toronto
Pham, Tài I.
Canada, Toronto
Saint Michael's Hospital University of Toronto
Canada, Toronto
University of Toronto
Bellani, Giacomo
Italy, Milan
Università Degli Studi Di Milano-bicocca
Italy, Monza
Azienda Ospedaliera San Gerardo Monza
Bos, Lieuwe D.J.
Netherlands, Amsterdam
Amsterdam Umc - University of Amsterdam
Fan, Eddy
Canada, Toronto
Mount Sinai Hospital of University of Toronto
Canada, Toronto
University of Toronto
Artigas, Antonio A.
Spain, Madrid
Centro de Investigación Biomédica en Red de Enfermedades Respiratorias
Brochard, Laurent Jean
Canada, Toronto
Saint Michael's Hospital University of Toronto
Canada, Toronto
University of Toronto
Schultz, Marcus Josephus
Netherlands, Amsterdam
Amsterdam Umc - University of Amsterdam
Thailand, Bangkok
Faculty of Tropical Medicine, Mahidol University
Laffey, John
Canada, Toronto
Saint Michael's Hospital University of Toronto
Canada, Toronto
University of Toronto
Ireland, Galway
University of Galway
Pesenti, Antonio Maria
Unknown Affiliation
Esteban, Andrés
Unknown Affiliation
Gattinoni, Luciano G.
Unknown Affiliation
van Haren, Frank M.P.
Unknown Affiliation
Larsson, Anders Sune
Unknown Affiliation
McAuley, Daniel F.
Unknown Affiliation
Ranieri, V. Marco
Unknown Affiliation
Rubenfeld, Gordon David
Unknown Affiliation
Thompson, Boyd Taylor
Unknown Affiliation
Wrigge, Hermann
Unknown Affiliation
Slutsky, Arthur S.
Unknown Affiliation
Ríos, Fernando Gonçalves
Unknown Affiliation
Sottiaux, Thierry M.
Unknown Affiliation
Lora, Fredy S.
Unknown Affiliation
Azevedo, Luciano César Pontes
Unknown Affiliation
Bugedo, Guillermo
Unknown Affiliation
Qiu, Haibo
Unknown Affiliation
González, Marco A.
Unknown Affiliation
Silesky, Juan
Unknown Affiliation
Cerný, Vladimír
Unknown Affiliation
Nielsen, Jonas
Unknown Affiliation
Jibaja, Manuel
Unknown Affiliation
Matamis, Dimitrios
Unknown Affiliation
Ranero, Jorge Luis M.
Unknown Affiliation
Amin, Pravin R.
Unknown Affiliation
Hashemian, Seyed Mohammad Reza
Unknown Affiliation
Clarkson, Kevin P.
Unknown Affiliation
Kurahashi, Kiyoyasu
Unknown Affiliation
Villagómez, Asisclo Jesús
Unknown Affiliation
Zeggwagh, Amine Ali
Unknown Affiliation
Heunks, Leo M.A.
Unknown Affiliation
Laake, Jon Henrik
Unknown Affiliation
Palo, Jose Emmanuel M.
Unknown Affiliation
do Vale Fernandes, Antero
Unknown Affiliation
Sǎndesc, Dorel
Unknown Affiliation
Arabi, Yaseen M.
Unknown Affiliation
Bumbasierevic, Vesna
Unknown Affiliation
Nín, Nicholas
Unknown Affiliation
Lorente, José Ángel A.
Unknown Affiliation
Larsson, Anders Olof
Unknown Affiliation
Piquilloud, Lise
Unknown Affiliation
Abrouk, Fekri
Unknown Affiliation
McNamee, Lia
Unknown Affiliation
Hurtado, Javier L.
Unknown Affiliation
Bajwa, Ed
Unknown Affiliation
d’Empaire, Gabriel
Unknown Affiliation
Sula, Hektor H.
Unknown Affiliation
Nunci, Lordian
Unknown Affiliation
Cani, Alma
Unknown Affiliation
Zazu, Alan
Unknown Affiliation
Dellera, Christian
Unknown Affiliation
Alejandro, Risso V.
Unknown Affiliation
Daldin, Julio
Unknown Affiliation
Vinzio, Mauricio
Unknown Affiliation
Fernández, Rubén Oscar
Unknown Affiliation
Cardonnet, Luis Pablo
Unknown Affiliation
Bettini, Lisandro Roberto
Unknown Affiliation
Bisso, Mariano Carboni
Unknown Affiliation
Osman, Emilio M.
Unknown Affiliation
Setten, Mariano G.
Unknown Affiliation
Lovazzano, Pablo
Unknown Affiliation
Álvarez, Javier Abades Vila
Unknown Affiliation
Villar, Veronica
Unknown Affiliation
Pozo, Norberto Christian
Unknown Affiliation
Grubissich, Nicolas
Unknown Affiliation
Plotnikow, Gustavo Adrián
Unknown Affiliation
Vásquez, Daniela Noris
Unknown Affiliation
Ilutovich, Santiago
Unknown Affiliation
Tiribelli, Norberto
Unknown Affiliation
Chena, Ariel
Unknown Affiliation
Pellegrini, Carlos Anibal
Unknown Affiliation
Saenz, María Gabriela
Unknown Affiliation
Estenssoro, Elisa
Unknown Affiliation
Brizuela, Matías
Unknown Affiliation
Gianinetto, Hernan
Unknown Affiliation
Gómez, Pablo Edgardo
Unknown Affiliation
Cerrato, Valeria I.
Unknown Affiliation
Bezzi, Marco Guillermo
Unknown Affiliation
Borello, Silvina A.
Unknown Affiliation
Loiacono, Flavia A.
Unknown Affiliation
Fernandez, Adriana M.
Unknown Affiliation
Knowles, Serena
Unknown Affiliation
Reynolds, Claire
Unknown Affiliation
Inskip, Deborah M.
Unknown Affiliation
Miller, Jennene J.
Unknown Affiliation
Kong, Jing
Unknown Affiliation
Whitehead, Christina
Unknown Affiliation
Bihari, Shailesh
Unknown Affiliation
Seven, Aylin
Unknown Affiliation
Krstevski, Amanda
Unknown Affiliation
Rodgers, Helen J.
Unknown Affiliation
Millar, Rebecca T.
Unknown Affiliation
McKenna, Toni E.
Unknown Affiliation
Bailey, Irene M.
Unknown Affiliation
Åneman, Erik Anders
Unknown Affiliation
Staudinger, Thomas
Unknown Affiliation
Wittebole, Xavier
Unknown Affiliation
Bulpa, Pierre A.
Unknown Affiliation
Depuydt, Pieter O.
Unknown Affiliation
Piras, Cláudio
Unknown Affiliation
Beloncle, François Michel
Unknown Affiliation
Cirone, Rob
Unknown Affiliation
Goligher, Ewan C.
Unknown Affiliation
Rittayamai, Nuttapol
Unknown Affiliation
Ferguson, Niall D.
Unknown Affiliation
Mehta, Sangeeta K.
Unknown Affiliation
Bruhn, Alejandro R.
Unknown Affiliation
Qiu, Haibo
Unknown Affiliation
An, Youzhong
Unknown Affiliation
Qin, Bingyu
Unknown Affiliation
Zhou, Suming
Unknown Affiliation
Jiménez, Juan Ignacio Silesky
Unknown Affiliation
Maca, Jan
Unknown Affiliation
Sklienka, Peter
Unknown Affiliation
Gjedsted, Jakob
Unknown Affiliation
Nielsen, Jonas Bille
Unknown Affiliation
Burtin, Philippe
Unknown Affiliation
Beuret, Pascal
Unknown Affiliation
Mercat, Alain
Unknown Affiliation
Carteaux, Guillaume
Unknown Affiliation
de Prost, Nicolas
Unknown Affiliation
Chiche, Jean Daniel
Unknown Affiliation
Daviaud, Fabrice
Unknown Affiliation
Fartoukh, Muriel Sarah
Unknown Affiliation
Dellamonica, Jean
Unknown Affiliation
Arnal, Jean Michel
Unknown Affiliation
Papazian, Laurent
Unknown Affiliation
Messika, Jonathan
Unknown Affiliation
Combes, Alain
Unknown Affiliation
Béduneau, Gaëtan
Unknown Affiliation
Zogheib, Élie H.
Unknown Affiliation
Dupont, Hervé
Unknown Affiliation
Besset, Sébastien L.
Unknown Affiliation
Danin, Pierre Éric
Unknown Affiliation
Badie, Julio C.
Unknown Affiliation
Schneider, Francis
Unknown Affiliation
Rigaud, Jean Philippe
Unknown Affiliation
Duranteau, Jacques
Unknown Affiliation
Chabanne, Russell
Unknown Affiliation
Richecoeur, Jack R.
Unknown Affiliation
Robine, Adrien
Unknown Affiliation
Dres, Martin
Unknown Affiliation
Demoule, Alexandre
Unknown Affiliation
Baboi, Loredana
Unknown Affiliation
Guérin, Claude
Unknown Affiliation
Krassler, Jens
Unknown Affiliation
Zacharowski, Kai D.
Unknown Affiliation
Meybohm, Patrick
Unknown Affiliation
Simon, Philipp
Unknown Affiliation
Mouloudi, Eleni K.
Unknown Affiliation
Jog, Sameer Arvind
Unknown Affiliation
Gurjar, Mohan
Unknown Affiliation
Baronia, Arvind Kumar
Unknown Affiliation
Ramakrishnan, N.
Unknown Affiliation
Nichol, Alistair D.
Unknown Affiliation
Spadaro, S.
Unknown Affiliation
Protti, Alessandro
Unknown Affiliation
Cortegiani, Andrea
Unknown Affiliation
Antonelli, Massimo M.
Unknown Affiliation
Montini, Luca Maria
Unknown Affiliation
Beck, Eduardo J.
Unknown Affiliation
Cinnella, Gilda
Unknown Affiliation
Fossali, Tommaso
Unknown Affiliation
Colombo, Riccardo
Unknown Affiliation
Mojoli, Francesco
Unknown Affiliation
Foti, Giuseppe
Unknown Affiliation
Brazzi, Luca
Unknown Affiliation
Iotti, Giorgio Antonio
Unknown Affiliation
Ñamendys-Silva, Silvio A.
Unknown Affiliation
Sanchez-Hurtado, Luis A.
Unknown Affiliation
del Carmen Marín, María
Unknown Affiliation
Dendane, Tarek
Unknown Affiliation
Balkhi, Hicham
Unknown Affiliation
Elkhayari, Mina
Unknown Affiliation
Samkaoui, Nacer
Unknown Affiliation
Ezzouine, Hanane
Unknown Affiliation
Benslama, Abdellatif
Unknown Affiliation
Amor, Mourad
Unknown Affiliation
Maazouzi, Wajdi
Unknown Affiliation
Schouten, Jeroen A.
Unknown Affiliation
Heunks, Leo M.A.
Unknown Affiliation
Browne, Troy S.
Unknown Affiliation
Navarra, Leanlove
Unknown Affiliation
Hunt, Anna L.
Unknown Affiliation
Newby, Lynette
Unknown Affiliation
McArthur, Colin J.
Unknown Affiliation
Andersen, Finn Husøy
Unknown Affiliation
Barratt-Due, Andreas
Unknown Affiliation
Söreide, Eldar
Unknown Affiliation
Andruszkiewicz, Pawel
Unknown Affiliation
Berger-Estilita, Joana M.
Unknown Affiliation
Tomescu, D. Rodica
Unknown Affiliation
Pǎpuricǎ, Marius
Unknown Affiliation
Gritsan, Alexey I.
Unknown Affiliation
Almekhlafi, Ghaleb A.
Unknown Affiliation
Maghrabi, Khalid A.
Unknown Affiliation
Salahuddin, Nawal
Unknown Affiliation
Aisa, Tharwat Mahmoud
Unknown Affiliation
Tabhan, Edgardo E.
Unknown Affiliation
Bolon, Stefan
Unknown Affiliation
Smith, Oliver I.
Unknown Affiliation
Mancebo, Jordi B.Y.J.
Unknown Affiliation
Aguirre-Bermeo, Hernán
Unknown Affiliation
Rialp, Gemma
Unknown Affiliation
Forteza, Catalina
Unknown Affiliation
Roche-Campo, Ferrán
Unknown Affiliation
Peñuelas, Óscar
Unknown Affiliation
Broman, Lars Mikael
Unknown Affiliation
Oscarsson, Anna
Unknown Affiliation
ElAtrous, Souheil
Unknown Affiliation
Bouchoucha, Slaheddine
Unknown Affiliation
Chouchene, Imed
Unknown Affiliation
Ouanes, Islem
Unknown Affiliation
Demirkiran, Oktay
Unknown Affiliation
Özçelik, Menekşe
Unknown Affiliation
Meço, Başak Ceyda Orbey
Unknown Affiliation
Kakar, Vivek
Unknown Affiliation
Humphreys, Sally K.
Unknown Affiliation
Ferguson, Andrew J.
Unknown Affiliation
Raj, Ashok Sundai
Unknown Affiliation
Kannan, Santhanagopalan G.
Unknown Affiliation
Camsooksai, Julie
Unknown Affiliation
Dempsey, Ged A.
Unknown Affiliation
McKechnie, Stuart R.
Unknown Affiliation
Hutton, Paula J.
Unknown Affiliation
Di Tomasso, Nora
Unknown Affiliation
Dawson, Heidi
Unknown Affiliation
Williams, Alexandra J.
Unknown Affiliation
Boyd, Owen F.
Unknown Affiliation
de Gordoa, Laura Ortiz Ruiz
Unknown Affiliation
Szakmany, Tamas
Unknown Affiliation
Welters, Ingeborg Dorothea M.
Unknown Affiliation
Careless, Jon P.
Unknown Affiliation
Wise, Matt P.
Unknown Affiliation
Cole, Jade M.
Unknown Affiliation
Beitler, Jeremy R.
Unknown Affiliation
Bauer, Philippe R.
Unknown Affiliation
Batra, Hitesh
Unknown Affiliation
Kheir, Fayez M.
Unknown Affiliation
Baron, Rebecca M.
Unknown Affiliation
Bumbaširević, Vesna D.
Unknown Affiliation
Jovanović, Bojan M.
Unknown Affiliation
Statistics
Citations: 42
Authors: 251
Affiliations: 9
Identifiers
Doi:
10.1007/s00134-018-5152-6
ISSN:
03424642
Research Areas
Cancer
Health System And Policy
Study Design
Cross Sectional Study