Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
No improvement of survival with reduced- versus high-intensity conditioning for allogeneic stem cell transplants in Ewing tumor patients
Annals of Oncology, Volume 22, No. 7, Year 2011
Notification
URL copied to clipboard!
Description
Background: Outcomes of Ewing tumor (ET) patients treated with allogeneic stem cell transplantation (allo-SCT) were compared regarding the use of reduced-intensity conditioning (RIC) and high-intensity conditioning (HIC) regimens as well as human leukocyte antigen (HLA)-matched and HLA-mismatched grafts. Patients and methods: We retrospectively analyzed data of 87 ET patients from the European Group for Blood and Marrow Transplantation, Pediatric Registry for Stem Cell Transplantations, Asia Pacific Blood and Marrow Transplantation and MetaEICESS registries treated with allo-SCT. Fifty patients received RIC (group A) and 37 patients received HIC (group B). Twenty-four patients received HLA-mismatched grafts and 63 received HLA-matched grafts. Results: Median overall survival was 7.9 months [±.24, 95% confidence interval (CI) 5.44-10.31] for group A and 4.4 months (±1.06, 95% CI 2.29-6.43) for group B patients (P = 1.3). Death of complications (DOC) occurred in 4 of 50 (0.08) and death of disease (DOD) in 33 of 50 (0.66) group A and in 16 of 37 (0.43) and 17 of 37 (0.46) group B patients, respectively. DOC incidence was decreased (P < 0.01) and DOD/relapse increased (P < 0.01) in group A compared with group B. HLA mismatch was not generally associated with graft-versus-Ewing tumor effect (GvETE). Conclusions: There was no improvement of survival with RIC compared with HIC due to increased DOD/relapse incidence after RIC despite less DOC incidence. This implicates general absence of a clinically relevant GvETE with current protocols. © The Author 2011. Published by Oxford University Press on behalf of the European Society for Medical Oncology. All rights reserved.
Authors & Co-Authors
Thiel, U.
Germany, Munich
Technische Universität München
Wawer, Angela
Germany, Munich
Technische Universität München
Wolf, Petra
Germany, Munich
Klinikum Rechts Der Isar
Badoglio, M.
France, Paris
Ap-hp Assistance Publique - Hopitaux de Paris
Santucci, A.
Italy, Perugia
Università Degli Studi Di Perugia
Klingebiel, Thomas Erich
Germany, Frankfurt am Main
Goethe-universität Frankfurt am Main
Basu, O.
Germany, Frankfurt am Main
Goethe-universität Frankfurt am Main
Borkhardt, Arndt K.
Germany, Dusseldorf
Heinrich-heine-universität Düsseldorf
Laws, Hans Jürgen
Germany, Dusseldorf
Heinrich-heine-universität Düsseldorf
Kodera, Y.
Japan, Nagakute
Aichi Medical University
Japan, Nagoya
Nagoya University School of Medicine
Yoshimi, Ayami
Japan, Nagoya
Nagoya University School of Medicine
Peters, Christina
Austria, Vienna
St Anna Kinderspital, Vienna
Ladenstein, R.
Austria, Vienna
St Anna Kinderspital, Vienna
Pession, Andrea
Italy, Bologna
Irccs Azienda Ospedaliero-universitaria Di Bologna
Prete, Arcangelo
Germany, Munich
Technische Universität München
Urban, E. C.
Austria, Graz
Medizinische Universität Graz
Schwinger, W.
Austria, Graz
Medizinische Universität Graz
Bordigoni, Pierre
France, Vandoeouvre-les-nancy
Hôpital Brabois Adultes
Salmon, A.
France, Vandoeouvre-les-nancy
Hôpital Brabois Adultes
Ángel Díaz, Miguel Ángel D.
Spain, Madrid
Hospital Infantil Universitario Niño Jesús
Afanasyev, Boris V.
Russian Federation, Saint Petersburg
Pavlov University
Lisukov, Igor A.
Russian Federation, Saint Petersburg
Pavlov University
Morozova, E.
Russian Federation, Saint Petersburg
Pavlov University
Toren, Amos
Israel, Tel Hashomer Tel Aviv
Chaim Sheba Medical Center Israel
Bielorai, B.
Israel, Tel Hashomer Tel Aviv
Chaim Sheba Medical Center Israel
Korsakas, J.
Lithuania, Vilnius
Vilniaus Universitetas
Fagioli, Franca
Italy, Turin
Ospedale Infantile Regina Margherita
Caselli, Désirée
Italy, Florence
Azienda Ospedaliero-universitaria Meyer
Ehninger, Gerhard E.
Germany, Dresden
Universitätsklinikum Carl Gustav Carus Dresden
Gruhn, B.
Germany, Jena
Friedrich-schiller-universität Jena
Dirksen, U.
Germany, Munster
Universitätsklinikum Münster
Abdel-Rahman, Fawzi Latif
Jordan, Amman
King Hussein Cancer Center
Aglietta, M.
Unknown Affiliation
Mastrodicasa, E.
Italy, Perugia
Università Degli Studi Di Perugia
Torrent, M.
Spain, Barcelona
Hospital de la Santa Creu I Sant Pau
Corradini, Paolo
Italy, Milan
Università Degli Studi Di Milano
Déméocq, François
France, Clermont-ferrand
Université Clermont Auvergne
Dini, Giorgio
Italy, Genoa
Istituto Giannina Gaslini
Dreger, Peter
Germany, Heidelberg
Universität Heidelberg
Eyrich, M.
Germany, Wurzburg
Julius-maximilians-universität Würzburg
Goździk, Jolanta
Poland, Krakow
Uniwersytecki Szpital Dziecięcy w Krakowie
Guilhot, François
France, Poitiers
Centre Hospitalier Universitaire de Poitiers
Holler, Ernst
Germany, Regensburg
Universität Regensburg
Kościelniak, Ewa
Germany, Stuttgart
Klinikum Stuttgart Olgahospital
Messina, Chiara
Italy, Padua
Azienda Ospedale Università Padova
Nachbaur, D.
Austria, Innsbruck
Landeskrankenhaus Innsbruck
Sabbatini, R.
Italy, Modena
Azienda Ospedaliero - Universitaria Di Modena
Oldani, E.
Italy, Bergamo
Ospedali Riuniti Di Bergamo
Ottinger, H.
Germany, Essen
Universitätsklinikum Essen
Ozsahin, H.
Switzerland, Geneva
Hopital Des Enfants, Hôpitaux Universitaires de Genève
Schots, Rik
Belgium, Jette
Universitair Ziekenhuis Brussel
Siena, Salvatore
Italy, Milan
Asst Grande Ospedale Metropolitano Niguarda
Stein, Jerry
Israel, Petah Tiqwa
Schneider Childrens Medical Center Israel
Sufliarska, Sabina
Slovakia, Bratislava
Comenius University Medical School
Ünal, Ali Ekrem
Turkey, Kayseri
Kapadokya Bmt Center
Ussowicz, M.
Poland, Wroclaw
Wroclaw Medical University
Schneider, Pascale
France, Rouen
Hopital Charles Nicolle
Woessmann, Wilhelm
Germany, Giessen
Universitätsklinikum Gießen Und Marburg, Standort Gießen
Jürgens, H.
Germany, Munster
Universitätsklinikum Münster
Bregni, Marco
Italy, Milan
Ospedale San Giuseppe, Milano
Burdach, Stefan E.G.
Germany, Munich
Technische Universität München
Statistics
Citations: 61
Authors: 61
Affiliations: 47
Identifiers
Doi:
10.1093/annonc/mdq703
ISSN:
09237534
e-ISSN:
15698041
Research Areas
Cancer
Study Design
Cohort Study