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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
No association between antenatal common mental disorders in low-obstetric risk women and adverse birth outcomes in their offspring: Results from the CDS study in Ghana and Côte D'Ivoire
PLoS ONE, Volume 8, No. 11, Article e80711, Year 2013
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Description
Background: Evidence linking common mental disorders (CMD) in pregnant women to adverse birth outcomes is inconsistent, and studies often failed to control for pregnancy complications. This study aimed to explore the association between antenatal depression and anxiety symptoms and birth outcomes in a low-obstetric risk sample of mother/child dyads in Ghana and Côte d'Ivoire. Methods: In 2010-2011, a prospective cohort of 1030 women in their third trimester in Ghana and Côte d'Ivoire was enrolled. Depression and anxiety were assessed in the third trimester using the Patient Health Questionnaire depression module and the 7-item Generalized Anxiety Disorder scale. 719 mother/child dyads were included in the analysis. We constructed multivariate regression models to estimate the association between CMD and low birth weight (LBW), and preterm birth (PTB) to control for potential confounders. Results: The prevalence of depression and anxiety symptoms were 28.9% and 14.2% respectively. The mean birth weight was 3172.1g (SD 440.6) and the prevalence of LBW was 1.7%. The mean gestational age was 39.6 weeks and the proportion of PTB was 4%. Multivariate linear regression revealed no significant association between maternal depression (B=52.2, 95% CI -18.2 122.6, p=0.15) or anxiety (B=17.1, 95% CI -74.6 108.7, p=0.72) and birth weight. Yet, low socio-economic status, female sex of the child, and younger maternal age were associated with lower birth weight. Multivariate logistic regression suggested no significant association between maternal depression (OR: 2.1, 95% CI 0.8 5.6, p=0.15) or anxiety (OR: 1.8, 95% CI 0.6 5.5, p=0.29) with PTB. Conclusions: Our data suggests that depression and/or anxiety in the 3rd trimester of pregnancy are not independent predictors of adverse birth outcomes in low obstetric risk women. The role of pregnancy complications as confounders or effect modifiers in studies of maternal CMD and their impact on birth outcomes should be investigated. © 2013 Bindt et al.
Authors & Co-Authors
Bindt, Carola
Unknown Affiliation
Guo, Nan
Unknown Affiliation
Te Bonle, Marguerite D.
Unknown Affiliation
Appiah-Poku, J.
Unknown Affiliation
Hinz, Rebecca
Unknown Affiliation
Barthel, Dana
Unknown Affiliation
Schoppen, Stefanie
Unknown Affiliation
Feldt, Torsten
Unknown Affiliation
Barkmann, Claus
Unknown Affiliation
Koffi, Mathurin
Unknown Affiliation
Loag, Wibke
Unknown Affiliation
Nguah, Samuel Blay
Unknown Affiliation
Eberhardt, Kirsten Alexandra
Unknown Affiliation
Tagbor, Harry
Unknown Affiliation
N'Goran, Eliézer Kouakou
Unknown Affiliation
Ehrhardt, Stephan
Unknown Affiliation
Statistics
Citations: 39
Authors: 16
Affiliations: 9
Identifiers
Doi:
10.1371/journal.pone.0080711
e-ISSN:
19326203
Research Areas
Health System And Policy
Maternal And Child Health
Mental Health
Sexual And Reproductive Health
Study Design
Cross Sectional Study
Cohort Study
Study Locations
Ghana
Ivory Coast
Participants Gender
Female